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"Vitamin D" - Marshall Protocol perspective
8000 IU per day is a lot if he did it for many months. I got confused reading Vit D literature, there doesn't seem to even be concensus on what is an optimal blood level and what constitutes a toxic level.
I suspect that it is best to avoid supplemental D and to just sunbath or use a high UVB tanning bed regularly. At no point in human history have we consumed large amounts of Vit D. There will be complex biological processes at play for regulating and using Vit D from the skin. There will be feedback systems that affect other systems in the body. Taking a Vit D capsule bypasses all of that...
I remember looking at those Sperti lamps but they need replacement bulbs that need to be ordered internationally and would be awkward to use compared with visiting a tanning salon if you wanted full body coverage. Fortunately I now live in a latitude where the UVB is high all year round.
Going on holiday to a tropical location in the middle of winter and spending two weeks in the sun will recharge one's D reserves and allow one to rely solely on the sun even if they live at a high latitude.
Sperti lamp bulbs lasts 1000 hours and on average you only need to use it 5 min three times a week. So those bulbs last 76 years before you need to replace them. How many bulb cycles are you going to spent on this life? 🙂
Bioessays
2008 Feb;30(2):173-82.
Vitamin D Discovery Outpaces FDA Decision Making
- School of Biological Sciences and Biotechnology, Murdoch University, Western Australia. trevor.m@autoimmunityresearch.org
- PMID: 18200565
Abstract
The US FDA currently encourages the addition of vitamin D to milk and cereals, with the aim of reducing rickets in children and osteoporosis in adults. However, vitamin D not only regulates the expression of genes associated with calcium homeostasis, but also genes associated with cancers, autoimmune disease, and infection. It does this by controlling the activation of the vitamin D receptor (VDR), a type 1 nuclear receptor and DNA transcription factor. Molecular biology is rapidly coming to an understanding of the multiplicity of roles played by the VDR, but clinical medicine is having difficulty keeping up with the pace of change. For example, the FDA recently proposed a rule change that will encourage high levels of vitamin D to be added to even more foods, so that the manufacturers can claim those foods "reduce the risk of osteoporosis". The FDA docket does not review one single paper detailing the transcriptional activity of vitamin D, even though, on average, one new paper a day is being published on that topic. Nor do they review whether widespread supplementation with vitamin D, an immunomodulatory secosteroid, might predispose the population to immune dysfunction. This BioEssay explores how lifelong supplementation of the food chain with vitamin D might well be contributing to the current epidemics of obesity and chronic disease.
Quote from Sam on May 27, 2020, 3:17 amSperti lamp bulbs lasts 1000 hours and on average you only need to use it 5 min three times a week. So those bulbs last 76 years before you need to replace them. How many bulb cycles are you going to spent on this life?
Haha I thought you might have a response to that, ok fair enough. Perhaps it is a better option than tanning units for some. When I lived in a high latitude city I used to use a vertical stand in tanning unit a couple of times a week on the way home from work. If that hadn't of been so convenient then perhaps a Sperti lamp would have been more suitable.
https://mpkb.org/home/tests/vitdinterpretation
on-line calculator with entry boxes for both 25-D and 1,25-D
https://www.bbc.com/news/world-europe-45809419
Brazil was first to ban sunbeds in 2009, with the only exception if doctors prescribed their use for health reasons. The same year the World Health Organization (WHO) classified exposure to UV sunlamps, sunbeds and tanning booths as carcinogenic to humans.
Australia followed in 2013.
Studies show 40% of Australians are Vit D deficient and they've banned sunbeds...
So the whole population in the southern states in the winter is supposed to take Vit D capsules and get regular blood tests when the science itself hasn't even come to any strong consensus about deficiency and toxicity levels? 🙁
Heliotherapy was recommended by Hippocrates and has proven to be effective over thousands of years including in modern times. Is D supplementation even proven to give the same benefits as sun exposure?
Quote from Sam on May 27, 2020, 1:34 amI think it is very individual how different people react to vitamin d supplements. Like one case where 72 year old man started to have parkinson's disease symptoms. What they found out that the man had supplemented vitamin d, if I remember correctly, it was just 8000 IU per day and his d level wasn't even in the toxic range with that amount. So they made him stop taking vitamin d and ta-da, his parkinson's disease was cured.
If you can't get vitamin d from the sun then I strongly suggest that you go and buy Sperti vitamin d lamp. It's quite pricey to order it from USA to Europe, but what can you do, just do it.
Some people have skin issues or can't handle oxidative damage from UVB or simply live somewhere up in Russia and don't have much money. For them is (cheap) D3 supplement only choice.. Btw if someone deficient in vit D has shut down immune system and starts taking D. You can feel a lot of all kinds of health issues, because your immune system is going back on line.. During my worst years I wasn't sick at all. No high temperature nothing. My body was not able to fight any bugs, virus, bacteria nothing.. It is funny how some people are saying that they have so strong immune system they haven't been sick for 10 years. But they don't realize that it is sign of non functioning immune system lol. When somebody catch something he should have fever, he should feel bad from body releasing hydrogen peroxide. That's how the body kills bacteria and viruses. But people as they get older or sicker. Their body can't afford doing a lot of oxidative stress to kill the bugs or they are simply D deficient and their body doesn't even have that ability.. When I was slowly going better I had after 5+ years without fever so strong periods of sickness that I was thinking this is the end.. 😀
If the MP folks are right about low 25-D levels resulting from, not causing, illness, then not measuring the active metabolite 1,25-D is just plain stupid. Here's one recent "expert" report. I'll bet a dime to a dollar the 10-country data does not include testing 1,25-D, which requires freezing the blood after draw and keeping it frozen on the way to the lab and analyzed within 72 hours. They're looking at the same thing the vast majority of North American labs are cranking-out on the cheap - 25-D levels. It's likely that our "experts" on Vitamin D are simpletons, just like our "experts" on Vitamin A. As Trevor Marshall opined in 2008: "Molecular biology is rapidly coming to an understanding of the multiplicity of roles played by the VDR, but clinical medicine is having difficulty keeping up with the pace of change."
https://www.sciencedaily.com/releases/2020/05/200507121353.htm
Vitamin D levels appear to play role in COVID-19 mortality rates
Patients with severe deficiency are twice as likely to experience major complications
- Date: May 7, 2020
- Source: Northwestern University
- Summary: Researchers analyzed patient data from 10 countries. The team found a correlation between low vitamin D levels and hyperactive immune systems. Vitamin D strengthens innate immunity and prevents overactive immune responses. The finding could explain several mysteries, including why children are unlikely to die from COVID-19.
Ann N Y Acad Sci
2009
Reversing Bacteria-Induced Vitamin D Receptor Dysfunction Is Key to Autoimmune Disease
Joyce C Waterhouse 1, Thomas H Perez, Paul J Albert
(1) Autoimmunity Research Foundation, Thousand Oaks, California 91360, USA.
PMID: 19758226
Abstract
Vitamin D research is discussed in light of the hypothesis that the lower average levels of vitamin D frequently observed in autoimmune disease are not a sign of deficiency. Instead, it is proposed that the lower levels result from chronic infection with intracellular bacteria that dysregulate vitamin D metabolism by causing vitamin D receptor (VDR) dysfunction within phagocytes. The VDR dysfunction causes a decline in innate immune function that causes susceptibility to additional infections that contribute to disease progression. Evidence has been accumulating that indicates that a number of autoimmune diseases can be reversed by gradually restoring VDR function with the VDR agonist olmesartan and subinhibitory dosages of certain bacteriostatic antibiotics. Diseases showing favorable responses to treatment so far include systemic lupus erythematosis, rheumatoid arthritis, scleroderma, sarcoidosis, Sjogren's syndrome, autoimmune thyroid disease, psoriasis, ankylosing spondylitis, Reiter's syndrome, type I and II diabetes mellitus, and uveitis. Disease reversal using this approach requires limitation of vitamin D in order to avoid contributing to dysfunction of nuclear receptors and subsequent negative consequences for immune and endocrine function. Immunopathological reactions accompanying bacterial cell death require a gradual elimination of pathogens over several years. Practical and theoretical implications are discussed, along with the compatibility of this model with current research.
this might be a neat experiment to try, for those of us making slow-progress with VA-reduction. I'm thinking all this stuff is intimately interconnected: retinoic acid induced inflammation, bacterial infections, VDR dysfunction, cytokine storm, etc.
Immunol Res - 2017 Feb;65(1):129-135.
Electrosmog and Autoimmune Disease
Trevor G Marshall 1, Trudy J Rumann Heil 2
PMID: 27412293
Abstract
Studies in mice have shown that environmental electromagnetic waves tend to suppress the murine immune system with a potency similar to NSAIDs, yet the nature of any Electrosmog effects upon humans remains controversial. Previously, we reported how the human Vitamin-D receptor (VDR) and its ligand, 1,25-dihydroxyvitamin-D (1,25-D), are associated with many chronic inflammatory and autoimmune diseases. We have shown how olmesartan, a drug marketed for mild hypertension, acts as a high-affinity partial agonist for the VDR, and that it seems to reverse disease activity resulting from VDR dysfunction. We here report that structural instability of the activated VDR becomes apparent when observing hydrogen bond behavior with molecular dynamics, revealing that the VDR pathway exhibits a susceptibility to Electrosmog. Further, we note that characteristic modes of instability lie in the microwave frequency range, which is currently populated by cellphone and WiFi communication signals, and that the susceptibility is ligand dependent. A case series of 64 patient-reported outcomes subsequent to use of a silver-threaded cap designed to protect the brain and brain stem from microwave Electrosmog resulted in 90 % reporting "definite" or "strong" changes in their disease symptoms. This is much higher than the 3-5 % rate reported for electromagnetic hypersensitivity in a healthy population and suggests that effective control of environmental Electrosmog immunomodulation may soon become necessary for successful therapy of autoimmune disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406447/pdf/12026_2016_Article_8825.pdf