I needed to disable self sign-ups because I’ve been getting too many spam-type accounts. Thanks.
"Vitamin D" - Marshall Protocol perspective
Some anti MP stuff, for balance:
https://bmjopenrespres.bmj.com/content/4/1/e000211
25(OH)D3 deficiency was associated with lower ASL antimicrobial activity
We hypothesised that subjects with serum vitamin D3 deficiency (<20 ng/mL) would have lower ASL antimicrobial activity compared with non-deficient subjects (≥20 ng/mL). To investigate the effect of vitamin D3 deficiency on ASL antimicrobial activity, we paired RLU values in the samples with their respective serum 25(OH)D3 regardless of allocation group (vitamin D3 or placebo) or whether they were baseline or postintervention samples. Thereafter, we compared the amount of live bacteria after challenge in the ASL samples with a clinically deficient 25(OH)D3 serum concentration to the samples with non-deficient levels. We found that ASL samples associated with vitamin D3 deficiency had significantly more live bacteria after challenge compared with non-deficient subjects (6394±289, n=16 vs 5646±129, n=64 respectively, p=0.0136 by unpaired t-test). These data suggest that vitamin D3 deficiency is associated with a decrease in ASL antimicrobial activity.
I was thinking about the possible benefits of NOT sunning and wondered if VA's broken down by sunlight are problematic.
A person trying to base the decision to allow sunlight on the face might get pretty confused when looking back at tradtions, because yes, loads of people got tons of sunlight... and yet parasols and big hats and sombreros were a part of life too.
Personally, I fall in the middle, trying to get a DOSE of sunlight on my skin, 5-10 minutes-- but reaching for the sombrero otherwise. I feel it is what I'm up to...Not baking like a potato in the sun yet.
I do, however, know people who get loads of sunlight who seem very at home on the planet and in their bodies.
Carotenoids and retinoids make sun exposure and smoking more dangerous.
Perspective
Regarding human toxicity, the long-term consequences of using cosmetics containing RP are currently unknown. It has been demonstrated that photoirradiation of RP can result in forming toxic photodecomposition products, generate ROS, induce lipid peroxidation, and cause DNA damage. Also, topically applied RP produces many of the cutaneous changes associated with the use of drug products containing RA which in some instances can enhance photocarcinogenesis. Thus, a study of the photocarcinogenesis of RP, under conditions relevant to the use of RP in cosmetics, is timely and important. As a consequence, RP has recently been nominated by the U.S. FDA and selected by the National Toxicology Program (NTP) as a high priority compound for phototoxicity and photocarcinogenicity studies. The goal of these studies is to provide relevant information necessary for risk assessment of RP in cosmetic creams.
Retinoic Acid Induces Hyperactivity, and Blocking Its Receptor Unmasks Light Responses and Augments Vision in Retinal Degeneration
https://www.sciencedirect.com/science/article/pii/S0896627319301242
Here we show that retinoic acid (RA), signaling through its receptor (RAR), is the trigger for hyperactivity. A genetically encoded reporter shows elevated RAR signaling in degenerated retinas from murine RP models. Enhancing RAR signaling in healthy retinas mimics the pathophysiology of degenerating retinas.
lmao:
https://scienceblogs.com/insolence/2012/08/03/15-years-of-promoting-quackery
Accused by feds, sun bed-selling doctor settles for up to $5.3 million
https://www.chicagotribune.com/business/ct-sunbed-doc-settles-0415-biz-20160414-story.html
https://www.consumer.ftc.gov/blog/2017/02/259-million-refunds-mercola-tanning-beds
@rockarolla Hehe I was banned from Morley Robbins facebook group really fast when I was asking some questions.
I think they need to shorten the podcast haha, I didn't listen, were there any key points?
At the start he says vitamin D is a hormone, I know what they mean but technically we need to make a distinction between calcidiol and calcitriol. When the hormone like metabolite calcitriol is high from excess supplementation that's bad but my understanding is you need to take a lot of calcidiol to do that, I'm not aware that lower levels of supplementation will cause that unless there is another causative factor such as excess retinoic acid.
So taking lots of vitamin D when one has Hypervitaminosis A may not be a good idea but I'm not convinced that supplementation of lower amounts is problematic. If calcitrol goes up in the absence of high dose supplementation I think the body is doing that for a reason such as protecting itself against excess retinoic acid. So one needs to address the cause of elevated calcitriol rather than avoid vitamin D.
I think that it's best to get vitamin D from the sun but if someone can't get their vitamin D that way then low dose supplementation is a good idea. Low dose as in RDA like amounts.
I wonder if some of the vit A metabolites could be a weak activators of VDR (and also preventing other molecules from binding) as opposed to strong calcitriol-based activation and even more stronger olmesartan-based one.
This could possibly explain why milk is so low in D and high in A.