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Wahl's talking vitamin A
It is kind of impossible to avoid supplements, since they put them in the food, LOL. I decided to make us Cream of Wheat this morning because it is comfort food that we like, and I looked at the package and it's heavily supplemented. So I gave us each a few drops of b12 to even out the playing field. (B12 wasn't an ingredient but many of the other B's are there).
I suppose that supplements are more like medicine and food is always your best bet. I'm tempted to try a sort of spring-cleanse middle-of-the-road between Grant and Wahls in which we go off all those foods that they both don't eat, no colorful veggies but white ones instead, and a small portion of liver once a week! Do some gut-biome-promotional stuff.
Hmm.... and of course: BIKING! 🙂
Anyone knows the half life of vit A ingested with, for example, milk?
I.e. when the sum of all vit A metabolites will return to a previous(base) level after say a cup of milk?
Does Retinol(Vitamin A) ingestion leads to [temporary] unbound retinoic acid spike?
Quote from tim on March 19, 2021, 11:50 pm
Many thanks Tim - exactly what I was looking for.
Wow:
FIGURE 4
Vitamin A as supplement :: S1: 3.0 mg, S2: 7.3 mg and S3: 14.6 mg (A)
Vitamin A as liver paste :: L1 3.0 mg, L2: 7.5 mg and L3: 15.0 mg.
(Vitamin A 1 IU is the biological equivalent of 0.3 micrograms (mcg) retinol, or of 0.6 micrograms beta-carotene)
Clear responses were found for 13-cis-4-oxo RA (Fig. 4). No maximum concentrations were reached within 10h after dosing although at ∼5 h some curves showed a first, small peak. The curves did not return to baseline within 24 h.
Responses were significantly higher after consumption of liver paste at 7.5 and 15 mg compared with the supplement. The AUC increased with dose for both sources, but the increase was greater for liver paste than for the supplement.
...
Identification of 9-cis-retinoic acid, 9,13-di-cis-retinoic acid, and 14-hydroxy-4,14-retro-retinol in human plasma after liver consumption
https://pubmed.ncbi.nlm.nih.gov/8809215/
Vitamin A is a well-established teratogen in several animal species. Case reports as well as a recent epidemiological study suggest that vitamin A intake in excess of 25,000 or 10,000 IU respectively, can result in retinoid-specific defects in the offspring. A single meal of liver contains, on the average, a 10- to 20-fold higher amount of vitamin A than what is already suspected to be teratogenic. To evaluate the risk of liver consumption during pregnancy, we have studied levels of vitamin A and a number of potentially active retinoid metabolites in plasma of ten healthy male volunteers following consumption of fried turkey liver (2 g raw weight/kg body weight). HPLC, UV spectroscopy and mass spectrometry were used for identification and quantitation of retinoids in plasma. As shown previously, vitamin A intake via liver consumption resulted in greatly increased plasma levels of 13-cis-retinoic acid (13-cis-RA) and 13-cis-4-oxo-RA, and low levels of all-trans-RA and all-trans-4-oxo-RA. In our present investigation 9-cis-RA, 9,13-di-cis-RA, and 14-hydroxy-4,14-retro-retinol (14-HRR) were identified for the first time in humans as physiological metabolites of vitamin A. 9-cis-RA is a potent teratogen as well as a high affinity ligand of retinoid receptors, and 14-HRR was previously shown to promote lymphocyte activation in vitro. The present study bears on the issue of a possible teratogenic risk of liver consumption, as active retinoids were identified in human plasma, and their levels could be related to previous human studies as well as to experimental studies in sensitive animal species.
^^^
Fried turkey liver was given as part of a light meal to ten healthy male volunteers (2 g raw weight/kg body weight). The vitamin A content in the liver (retinol plus retinyl esters) was determined by HPLC to be 0.5 +- 0.04 mg total retinal/g raw weight (n=3). Hence, the vitamin A intake was approximately 3,300 IU or 1 mg/kg body weight. Blood samples were taken into heparinized syringes before the meal and at eight time intervals after the meal (1, 2, 4, 6, 8, 10, 12, and 24 hours), and plasma was prepared. Three different methods were used for determination of retinoids by reversed-phase HPLC.
I just had a derpy moment when I realized that the interviewer in the original post is none other than the daughter of Jordan Peterson. LOL. At some point I'm going to have to start wearing my glasses.
And that led me to watch a bit of another interview in which she is answering questions about her father's recent hospitalization. (paradoxical reaction to prescribed drugs, withdrawal problems of longterm drugs, insomnia, which led to precipitous health crisis, covid and pneumonia and I think there was induced coma in there as well).
I can't help but wonder if that family has heard yet about Grant's Vitamin A idea.
I can't help but wonder if one of the things that has brought on the crisis was the fact that Jordan Peterson hasn't gotten "the ick" on the medical profession and it's potent interventions at this point. It is probably extremely hard for him since he is an MD (psychiatrist) himself, and a professor at a medical school, and imbedded pretty deeply in the medical paradigm. Look, I'm all for hitting the hospital for emergency medicine (like a broken leg) but when it comes to chronic complaints now... I'm very wary.
It appears his original problem was depression and anxiety.
I also wonder if he was undergoing harsh VA detox symptoms after his daughter convinced him to go carnivore. It was apparent from watching his more recent videos (before his sudden disappearance) that he had lost weight. I wonder if drug toxins were also stored along with VA in fat cells, and were unpacked at the same time.
Jordan Peterson and I are about the same age and lets just say that he WAS going through VA detox (unbeknownst to him).
Recently I posted about how some grief I was going through sent me into a physical tizzy.
Jordan Peterson's wife was diagnosed with cancer and that sent him into a tizzy, causing him to crank up his anxiety med dosage, ending in crisis.
I wonder if, like with myself, what he really needed was more nutritional support. I literally felt like a new person that week when I reached for the B complex.
Jordan Peterson had been on a high stress roll anyways. I bet he burns through his B vities. And he's older and perhaps needs more B12 too.
I definitely feel that I can't do the B's and B12 everyday. It's just way too much. Too much cure at one time! But I think it is what I need. A slow trickle of cure so my body can keep up.