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Why do women comprise 80% of all autoimmune disease cases?
I've written that my husband and I have seen a bit of different results from our "slow boat" of VA reduction.
I do think my husband is seeing some subtle results but hasn't lost any weight. He goes for yearly testing and I think some of his markers have improved, but he still needs blood pressure meds.
We may be at about the even mark "sickness"-wise... now... before Grant's idea I was the sickest.
Anyways (and this is right along for the last 30 years)
I exercise, he doesn't
I get sun, he doesn't
he has stress, I don't
I eat dairy, he doesn't
I drink, he hardly drinks
He eats fried foods, I don't
He is the body style to be fleshy, I'm more of a mid-style leaning toward skinny. I would guess that his body might choose to sock away VA in fat while mine doesn't...or even create fat for that purpose.
He has fatty liver and I don't.
I've never dieted FOR CALORIES but I've tried almost every "health" diet under the sun. He occasionally tries to diet for calories. (which I think is a terrible idea)
Because women get pregnant. Pregnancy increases the chance of autoimmunity. In fact, some conditions like scleroderma are almost exclusively found in parous women. One can write it off as a subset of reproduction-longevity tradeoff.
The likely cause is male fetal microchimerism and fetomaternal conflict. Pregnancy temporarily alleviates autoimmunity and later exacerbates it precisely because pregnancy is immunosuppressive, so once you regain your full immune function after giving birth you'll experience a rebound AND new autoimmunity from new foreign DNA.
As for the vitamin A angle - if I remember correctly women do not need as much of it, thus being more likely to suffer toxicity.
Quote from Anna2 on May 3, 2023, 10:49 amBecause women get pregnant. Pregnancy increases the chance of autoimmunity. In fact, some conditions like scleroderma are almost exclusively found in parous women. One can write it off as a subset of reproduction-longevity tradeoff.
The likely cause is male fetal microchimerism and fetomaternal conflict. Pregnancy temporarily alleviates autoimmunity and later exacerbates it precisely because pregnancy is immunosuppressive, so once you regain your full immune function after giving birth you'll experience a rebound AND new autoimmunity from new foreign DNA.
Statistically speaking parous women live longer. I think the health benefits of pregnancy probably stem from the very high levels of progesterone
Quote from salt on May 3, 2023, 1:44 pmQuote from Anna2 on May 3, 2023, 10:49 amBecause women get pregnant. Pregnancy increases the chance of autoimmunity. In fact, some conditions like scleroderma are almost exclusively found in parous women. One can write it off as a subset of reproduction-longevity tradeoff.
The likely cause is male fetal microchimerism and fetomaternal conflict. Pregnancy temporarily alleviates autoimmunity and later exacerbates it precisely because pregnancy is immunosuppressive, so once you regain your full immune function after giving birth you'll experience a rebound AND new autoimmunity from new foreign DNA.
Statistically speaking parous women live longer. I think the health benefits of pregnancy probably stem from the very high levels of progesterone
That is not true. Women who give birth later have a longer lifespan compared to women who gave birth early, however (life history theory). Increased parity also decreases the cumulative exposure to estrogen and progesterone (fewer menstrual cycles), not increases it.