Quote from Guest on February 9, 2019, 4:58 pm
Quote from Guest on February 5, 2019, 4:34 am
Quote from ggenereux on January 5, 2019, 9:41 am
Hi Liz,
RE: I used accutane twice in my late teens/early twenties. I did not notice any side effects of it then. Does that still mean I may have permanently damaged my protein building function?
No, not necessarily so. There are a lot of variables.
A good reference site is: https://www.acne.org/accutane.html
See:
https://static.acne.org/ipb_uploads/monthly_2018_08/03-isotretinoin-has-serious-side-effects.jpg.019cce70addbe13c524fd54d2bcd67d3.jpg
And:
https://static.acne.org/ipb_uploads/monthly_2018_08/04-side-effects-of-accutane-isotretinoin.jpg.21ba5567cceda7b349fc87951b2b0f30.jpg
Note the warning:
Isotretinoin affects the entire body and can change not only the skin, but the entire body for the rest of a person’s life. This is why it is only approved for severe nodulocystic acne.
Of course, that has not at all deterred many doctors from prescribing it for mild acne too. Nor, does the now reported 1,700+ suicides attributed to Accutane use, and the 7,000+ cases of IBD.
But, I don’t think the damage is entirely permanent. Once retinoic acid has bound itself to the RNA/DNA, and depending on how severely the genes are damaged by it, the cells will be then be subsequently producing defective proteins and enzymes. That effect could last as long as those cells remain alive. So, maybe about for 7 – 10 years.
That's an extremely interesting point Grant.
My name is Lee, I have shared some correspondence with you before by email. I have taken Accutane and am doing all I can to recover from this.
I've been doing a low Vitamin A diet eating mostly beef, potatoes and rice for months now. I've had a breakthrough and found what might be the missing link for me in the form of extended intermittent fasting.
Since doing daily 16/8 fasts and monthly 48 hour fasts the improvements in my fatigue, fibromyalgia type pain and sinus and eye issues has been dramatic.
I wonder if this could be because the longer fasts induce the natural process of autogphagy and perhaps speed up the regeneration of said defective proteins and enzymes you mention.
It's early days but I really believe the combination of low Vitamin A diet plus fasting will be the key to depleting my vitamin A levels and repairing the damage in the fastest possible time. It's already happening and i've tried everything including fecal microbial transplantation in my 5 years struggle post accutane.
Wishing everyone here the best of luck.
Regards,
Lee
Hi Lee, I am also a post accutane sufferer, and have recently started doing low Vit A also, would you be able to share some more info about your diet and fasting? Also you mention your symptoms as sinus and eye, I'm assuming dry eyes as I have these issues as well but dry eye is by far the most difficult and hard to manage. Would love to chat with you more, is there any chat feature on this forum?
Alex.
Quote from Guest on February 5, 2019, 4:34 am
Quote from ggenereux on January 5, 2019, 9:41 am
Hi Liz,
RE: I used accutane twice in my late teens/early twenties. I did not notice any side effects of it then. Does that still mean I may have permanently damaged my protein building function?
No, not necessarily so. There are a lot of variables.
A good reference site is: https://www.acne.org/accutane.html
See:
https://static.acne.org/ipb_uploads/monthly_2018_08/03-isotretinoin-has-serious-side-effects.jpg.019cce70addbe13c524fd54d2bcd67d3.jpg
And:
https://static.acne.org/ipb_uploads/monthly_2018_08/04-side-effects-of-accutane-isotretinoin.jpg.21ba5567cceda7b349fc87951b2b0f30.jpg
Note the warning:
Isotretinoin affects the entire body and can change not only the skin, but the entire body for the rest of a person’s life. This is why it is only approved for severe nodulocystic acne.
Of course, that has not at all deterred many doctors from prescribing it for mild acne too. Nor, does the now reported 1,700+ suicides attributed to Accutane use, and the 7,000+ cases of IBD.
But, I don’t think the damage is entirely permanent. Once retinoic acid has bound itself to the RNA/DNA, and depending on how severely the genes are damaged by it, the cells will be then be subsequently producing defective proteins and enzymes. That effect could last as long as those cells remain alive. So, maybe about for 7 – 10 years.
That's an extremely interesting point Grant.
My name is Lee, I have shared some correspondence with you before by email. I have taken Accutane and am doing all I can to recover from this.
I've been doing a low Vitamin A diet eating mostly beef, potatoes and rice for months now. I've had a breakthrough and found what might be the missing link for me in the form of extended intermittent fasting.
Since doing daily 16/8 fasts and monthly 48 hour fasts the improvements in my fatigue, fibromyalgia type pain and sinus and eye issues has been dramatic.
I wonder if this could be because the longer fasts induce the natural process of autogphagy and perhaps speed up the regeneration of said defective proteins and enzymes you mention.
It's early days but I really believe the combination of low Vitamin A diet plus fasting will be the key to depleting my vitamin A levels and repairing the damage in the fastest possible time. It's already happening and i've tried everything including fecal microbial transplantation in my 5 years struggle post accutane.
Wishing everyone here the best of luck.
Regards,
Lee
Hi Lee, I am also a post accutane sufferer, and have recently started doing low Vit A also, would you be able to share some more info about your diet and fasting? Also you mention your symptoms as sinus and eye, I'm assuming dry eyes as I have these issues as well but dry eye is by far the most difficult and hard to manage. Would love to chat with you more, is there any chat feature on this forum?
Alex.
