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All Roads Lead To Anhydroretinol: The Sneaky Vitamin A metabolite that causes Vitamin A Toxicity
Quote from tim on April 10, 2024, 7:34 pmYou're welcome. Yeah I think the science really indicates that it's extra important for those with certain SNPs to optimise their health as much as possible. SNPs mean reduced physiological function not absent physiological function. Physiological function that is often reduced by non genetic causes simultaneously.
Is your husband genetically susceptible to iron overload?
High fat diets tend to decrease insulin sensitivity whereas low fat high carb diets tend to increase insulin sensitivity. It's the opposite of what the low carb proponents say.
It's possible though that if certain micronutrients like choline and magnesium are sufficient on a high fat diet that decreased insulin sensitivity can be minimised.
Kwasniewski's diet is not a carnivore diet. It doesn't include much protein. He recommended a small amount of carbohydrate from potato or bread. I'm not recommending it just mentioning it because it would restrict both iron and manganese intake for people with hemochromatosis. He recommended multiple egg yolks per day and very fatty pork sausage.
He said that if one found a high fat diet unappealing one should consume a low fat high starch diet. In other words he thought it best to be in fat metabolism or glucose metabolism and not in glucose metabolism while consuming much fat. I'm not saying I agree with that, I see insulin resistance as being caused by liver dysfunction not by mixed carb fat diets. When fat intake goes up choline intake must too though otherwise NAFLD and insulin resistance can occur.
Egg yolks are very high in cholesterol and choline. Red meat is high in carnitine, cholesterol and choline. Increased choline and carnitine intake can increase TMA levels and a percentage of cholesterol oxidizes during cooking. Both TMA and oxysterols appear to be atherogenic. It's not known how significant this is though. The evidence points again to gut, kidney and liver health being the most important factor in terms of whether TMA and oxysterols are much of a problem or not.
There are two ways to reduce choline requirements. One is to reduce alcohol, sugar and fat intake and eat more grains, legumes and potatoes. The other is to increase trimethylglycine (betaine) intake. Unfortunately trimethylglycine can also convert into TMA though. Animal studies show that it can replace a large portion of choline requirements. The best source is quinoa followed by amaranth, wholegrain wheat, beet root and spinach.
Some foods such as garlic and olive oil reduce TMA production. People that consume a diet higher in plant foods appear to have less TMA producing flora. When researchers fed a steak to a vegan hardly any TMAO was produced.
TMA is metabolized into TMAO in the liver. TMAO appears to be correlated with heart disease. A Polish team has provided evidence to back up their hypothesis that TMA is the causative toxin, not TMAO as is more commonly believed.
I see a lower fat, lower sugar, lower animal product, high starch diet as the healthiest diet for most people. It's the most liver friendly way of eating.
When liver dysfunction occurs a lot of physiology is affected. That includes VDR receptor sensitivity and insulin receptor sensitivity. The solution to insulin resistance is not to avoid carbohydrates. It's to restore insulin sensitivity by improving liver function.
If aspirin causes gut permeability I don't think that's a good thing.
Exercise significantly improves insulin sensitivity.
I was writing a reply this morning and just tried posting it and I was logged out. So frustrating! So now this reply will be very truncated. (probably a good thing, I tend to overshare :/ )
Thanks for replying, I agree with you about the choline and TMA thing, I'm not sure which causes heart disease but it's clear that if you want to try to avoid TMA or TMAO you should avoid choline bitartrate. I tried telling Luke that. It easily degrades before you even take it. Terrible supplement. Egg yolks would be far better.
Not sure about my husband's iron status. He ancestry is from England mainly. He is also 1/16th native american. Doesn't appear like it at all though. he looks more like a viking. Used to be lean until I put him on the Ray Peat diet lol. Also convenience foods due to a stressful life situation, but he's struggled ever since losing any weight. I have tried getting him to eat lower fat, but he gets crazy cravings. He doesn't eat ice cream or a bunch of high fat dairy, but he will make large fatty burgers. Actually I get cravings as well eating too low fat. What would you recommend for cravings?
I also would like other's people's opinions on this catabolic/anabolic thing:
Click to access Anabolic-Imbalance-Reminders.pdf
Click to access Catabolic-Imbalance-Reminders3.pdf
It's based on Dr. Revici's work. I believe him because magnesium is supposed to be the most catabolic mineral and that's what happened to me I started getting bad insomnia after doing mag oil on my face every night for yrs. Also migraines that start on the back on the head which is listed on the symptoms list for catabolic imbalance. But I also can tend to be too anabolic at night, so the balance needs to be just right. When it is I can sleep through the night and have great energy.
Although Grant eats beef, his proportion of Fat (47g) or 9%, Proteins (121g) or 23%, and Carbohydrates (364g) or 68% aligns with this scenario.
47×9 + 121×4 + 364×4 = 2363 calories
"Most men over 60 need between 2,000 and 2,600 calories per day to maintain their weight, which is slightly less than younger men require."
Grant's caloric intake looks fine.
Yeah it's terrible when you spend a while writing a post then lose it somehow haha.
Yeah agree about choline bitartrate.
If cravings occur when lowering fat you might be going too low or not eating enough starch? Don't fight your instincts. When I said lower fat I just meant not excessive.
If someone is overweight but not over consuming calories then it's not a caloric issue. It's a liver health issue. It's a lack of exercise issue.
Have you tried giving him lecithin for a few months? 5-10 grams of lecithin per day may enable his liver to use his body stores of fat. If he is overweight then he will at least have subclinical NAFLD.
There are many dietary, lifestyle and health history factors that can influence one's health obviously. Causes vary on a case by case basis.
He could try a daily regimen of:
- 8 capsules NOW Non-GMO Lecithin 1200mg
- 250mg vitamin C
- 1 capsule Carlson's Tocomin SupraBio
- 1 capsule Swanson CoQ10 30mg
- 1/4 capsule Life Extension Mitochondrial Basics with PQQ
- 1/4 capsule Thorne Basic B Complex
This regimen should only be followed on a balanced high starch omnivorous liver friendly diet.
This can all be ordered off of iHerb.
This will provide liver support and enable it to start using fat reserves while processing toxins in the fat.
If he's depleting vitamin A 1 drop twice a week of Thorne vitamin K2 may be helpful.
@tim-2 Grant said he eats around 1500kcal. Which looks about right if all he eats is that small bowl of rice that I saw somewhere on the photo, some beans and some red meat 3 times a day..
@alexm Right now I eat 2x meat(chicken/turkey thigh, ground beef) with rice and white beans. 2x I have 25g whey protein with 20g hydrolyzed collagen. I have it with oats and some low oxalate seeds, shredded coconut and the scond time I have it with some bananas. Sometimes I add some olive oil to the meat, rice, beans. Sometimes I have also some masa harina tortillas and some sausages. It is like 3000kcal a day. I don't think it is some perfect diet for me now or something like that. I just ate it one day and so I keep eating it. I am so used to routines that sometimes even if I know it is not good for me I keep eating it. Hopefully I will move very soon to different country and there it will be completely different for sure. What will be available etc..
@jiri Nice I still think most oats are contaminated with glyphosate even the "organic" ones, for example in UK and Croatia when I tried the "organic" ones from each of these places they instantly gave me high glutamate autistic symptoms which I associate with glyphosate. But when I have these organic Amisa brand ones which are from Holland I don't get any of these symptoms and feel good from them, but I eat a lot of them everyday which I don't think is great as I think it is too much soluble fiber which slows down my bile and gut transit time, and sometimes I eat beans on top of that.
When people say oats spike blood sugar I think that is just because they are having glyohosate contaminated oats, because I don't get any symptoms like that at all maybe even the opposite.