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All Roads Lead To Anhydroretinol: The Sneaky Vitamin A metabolite that causes Vitamin A Toxicity
The amount of glyphosate intake from food is probably a few micrograms per day.
My understanding is it's far less toxic than something like cadmium or arsenic which we get more of. Most is quickly excreted.
There are studies where they give animals large doses to induce insulin resistance but is there any evidence that small microgram doses in food can cause much harm?
@david ?
Quote from tim on April 12, 2024, 3:47 amThe amount of glyphosate intake from food is probably a few micrograms per day.
My understanding is it's far less toxic than something like cadmium or arsenic which we get more of. Most is quickly excreted.
There are studies where they give animals large doses to induce insulin resistance but is there any evidence that small microgram doses in food can cause much harm?
@david ?
Glyphosate is one of the worst toxins for our health, If I eat a high arsenic food like brown rice I feel much better than lets say eating some grains that have glyphosate.
Thanks. I'll have a read.
Must say I'm skeptical though.
Seneff the author of that article is a computer scientist not a health scientist. She has some interesting hypotheses but there's no way I'd see any of them as facts. She is a WAPFer that thinks cholesterol is a nutrient.
Glyphosate has been studied for decades why is it suddenly being seen as so toxic? It's strange that the Monsanto Bayer merger occurred around the time the glyphosate legal issues began. This is considered one of the worst mergers in history. Did a company of that size really not do due diligence and see what was coming?
Bayer doesn't hold a patent for glyphosate and is moving more towards biotechnology and away from drugs and agricultural chemicals. In fact the future direction of food production is not agricultural at all. There is a move towards synthesizing glucose and starches in factories. What could possibly convince the public to adopt factory synthesized carbohydrates? Grain intolerances and allergies? Glyphosate fears?
Towards an Artificial Carbohydrates Supply on Earth
How to feed a growing global population in a secure and sustainable way? The conventional, biogenic agriculture has yet failed to provide a reliable concept which circumvents its severe environmental externalities—such as the massive use of land area, water for irrigation, fertilizer, pesticides, herbicides, and fossil fuel. In contrast, the artificial synthesis of carbohydrates from atmospheric carbon dioxide, water, and renewable energy would allow not only for a highly reliable production without those externalities, but would also allow to increase the agricultural capacities of our planet by several orders of magnitude. All required technology is either commercially available or at least developed on a lab-scale (at least for sugar).
@tim-2 https://raypeatforum.com/community/threads/roundup-glyphosate-finally-proven-toxic-it-depletes-glycine.11502/
Well glyphosate takes glycines place in the body so that messes with glutathione production and protein synthesis, glyphosate chelates essential minerals such as zinc, manganese, sulfur, copper. This is likely why you see many people with extremely low manganese levels on a HTMA test.
I don't think her being a computer scientist/engineer makes her lack credibility, in fact I think people from this field seem to possess a unique insight that regular scientists in the current biomedical field are lacking of.
For example Joshua Leisk another computer engineer who's work is based around reverse engineering CFS and mitochondrial dysfunction in diseases. His work is extremely complex and he goes very deep into the biochemistry and the biochemical cycles that go wrong in these conditions. As a computer engineer he says he likes puzzles so he wanted to solve the mystery of CFS/ME which modern medicine has deeply struggled with. And I would say his levels of understanding of biology and biochemistry are far above Grants and most doctors today.
https://bornfree.life/understanding-the-model/6/updated-disease-model-wip/45 - Here is his work if you wanted to check it out.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945755/ This study also confirms my suspicions that it is not actually gluten people are reacting to but glyphosate instead.
"Characteristics of celiac disease point to impairment in many cytochrome P450 enzymes, which are involved with detoxifying environmental toxins, activating vitamin D3, catabolizing vitamin A, and maintaining bile acid production and sulfate supplies to the gut. Glyphosate is known to inhibit cytochrome P450 enzymes."
Grant said glyphosate binds to the same nuclear membrane receptors as Retinoic Acid does.
I have to say I'm a bit shocked that you are downplaying glyphosates toxic effects I think you're very mistaken about this.
It was when I first developed Vitamin A toxicity I became extremely sensitive to glyphosate, so I know first hand how much of a neurotoxic poison glyphosate can be. And its link to conditions like Autism, ALS, Parkinson's, Alzheimers is very real.
Quote from tim on April 11, 2024, 8:58 pmYeah it's terrible when you spend a while writing a post then lose it somehow haha.
Yeah agree about choline bitartrate.
If cravings occur when lowering fat you might be going too low or not eating enough starch? Don't fight your instincts. When I said lower fat I just meant not excessive.
If someone is overweight but not over consuming calories then it's not a caloric issue. It's a liver health issue. It's a lack of exercise issue.
Have you tried giving him lecithin for a few months? 5-10 grams of lecithin per day may enable his liver to use his body stores of fat. If he is overweight then he will at least have subclinical NAFLD.
There are many dietary, lifestyle and health history factors that can influence one's health obviously. Causes vary on a case by case basis.
He could try a daily regimen of:
- 8 capsules NOW Non-GMO Lecithin 1200mg
- 250mg vitamin C
- 1 capsule Carlson's Tocomin SupraBio
- 1 capsule Swanson CoQ10 30mg
- 1/4 capsule Life Extension Mitochondrial Basics with PQQ
- 1/4 capsule Thorne Basic B Complex
This regimen should only be followed on a balanced high starch omnivorous liver friendly diet.
This can all be ordered off of iHerb.
This will provide liver support and enable it to start using fat reserves while processing toxins in the fat.
If he's depleting vitamin A 1 drop twice a week of Thorne vitamin K2 may be helpful.
Thanks, yeah I likely just don't eat enough overall when going lower fat. I started pigging out on dried cranberries, like 1/2 cup a day lol. That a lot of sugar. I'm more balanced now adding back in some dairy and also apple juice and don't have cravings. I can't seem to do a diet lacking in any sugar especially when going lower in fat.
Yeah what's interesting is I tried having him take taurine for a while, he didn't notice anything. Lol that's basically everything I've ever tried on him.
I had him on 4 grams of vitamin C for yrs, he's down to taking just a small amount as I became aware that taking too much is not good. I was a believer in orthomolecular medicine for a number of yrs.
He takes some thiamine, and I have haidut's idealabs b vitamins, but that lacks folate and b12, I'm still uncertain on bcomplexes. I find people who have histamine problems tend to have more histamine on bvitamins, but maybe a low dose would be fine.
He has mucus problems, I think he's dairy sensitive, but he's never gone more than like 2 weeks off dairy.
Lecithin/choline is something I've never experimented with, I'm very curious even though I really really didn't want to add any more supplements to my supplement graveyard! You don't think egg yolks could be tried first? Maybe one a day for a while?
He's honestly a very robust person right now, just has a very big gut.
I'm not downplaying anything I'm questioning the toxicity of the sub 1 mcg amounts consumers are exposed to. I'm not boldly stating it's not a big issue as you did with electrosmog.
It makes sense to just assume that glyphosate is extremely toxic until one realises how much this would affect people's diet and lifestyle. One is basically restricted to only eating organic food prepared at home. According to you though even that isn't enough because organic foods can contain it. So it's important to really question how toxic it is before spreading information that will be a source of stress in people's lives.
It isn't a fact that glycine substitution occurs, it's a hypothesis.
Facts and Fallacies in the Debate on Glyphosate Toxicity
"First, Samsel and Seneff argue that since glyphosate can potentially form N-substituted glycine polymers known as peptoids (31), then it can also replace glycine in regular polypeptides. However, as peptoids are laboratory creations that do not exist naturally in living organisms, it is not valid to extrapolate from these laboratory-manufactured entities to suggest that glyphosate can substitute for glycine in naturally occurring polypeptides, which are biosynthetically and structurally distinct from peptoids. In this context, it is perhaps also noteworthy that to the best of our knowledge, there are no reports of glyphosate peptoids having been generated."
"Finally, direct experimentation has shown that glyphosate does not incorporate into proteins (33). In these studies, E. coli were cultured in the presence of high concentrations (1 g/L) of glyphosate and rescued by addition of aromatic amino acids in the culture medium. Analysis of these bacteria showed that they possessed proteins with the exact same molecular weight as in non-exposed control cultures (33), demonstrating that glyphosate could not have been incorporated in place of glycine. Alternatively, the culture of E. coli in the presence of glyphosate and 6-fluorotryptophan resulted in polypeptides containing this variant aromatic amino acid and no incorporation of glyphosate (34). If glyphosate had been incorporated into the proteins of these bacteria, a shift in protein molecular weight would have occurred and would have been readily detectable by the sensitive and accurate mass spectroscopic analytical methods employed in these studies (33, 34)."
You wrote:
I don't think her being a computer scientist/engineer makes her lack credibility, in fact I think people from this field seem to possess a unique insight that regular scientists in the current biomedical field are lacking of.
Computer scientists have to understand large systems well and in software engineering there is no error tolerance so one tends to develop strong attention to detail.
It's a different skillset though and it's illogical to blindly accept that someone from a different field without decades of experience in a biomedical field has more mastery than everyone in that field.
What I see more commonly is someone from a different field or someone that is of a relevant field but not a scientist thinking they know more about health or nutrition than they actually do and developing a following online while giving people very flawed information based on untested hypotheses or pseudoscience that contradicts known science.
You seem like a decent and intelligent person but many of the ideas you post about here come from people like that.
The article above also responds to Seneff's claims about CYP450.
I'll try to check out Leisk's work sometime.
Eggs provide choline but can also cause gallbladder issues perhaps by thickening bile.
If someone has a big gut they will at least have subclinical NAFLD. Phosphatidylcholine is the most important nutrient to address that. More PC than you'll get from one egg is probably required. One egg + 10 grams of lecithin is what I would expect would be optimal to facilitate weight loss. I'd be surprised if that combined with plenty of walking and resistance training didn't result in significant weight loss.
Do you sunbathe? I see it as crucial to health. Winter or summer if it's a sunny day I'll try to get some sunbathing in.
Quote from tim on April 12, 2024, 8:22 pmEggs provide choline but can also cause gallbladder issues perhaps by thickening bile.
If someone has a big gut they will at least have subclinical NAFLD. Phosphatidylcholine is the most important nutrient to address that. More PC than you'll get from one egg is probably required. One egg + 10 grams of lecithin is what I would expect would be optimal to facilitate weight loss. I'd be surprised if that combined with plenty of walking and resistance training didn't result in significant weight loss.
Do you sunbathe? I see it as crucial to health. Winter or summer if it's a sunny day I'll try to get some sunbathing in.
Yes I agree he likely has NAFLD. I will get some lecithin. I guess I never thought it was as simple as just getting more choline. But it would be great if that's the case! Might be why he wants so much meat. It is pretty high in choline as well. But the iron may be a limiting factor.
Yes I get a lot of UVB, I moved to Florida from the north 4 yrs ago, lots of sunshine here! I don't see it as a priority anymore to intentionally lay in the sun as it's just so intense and my skin has more signs of aging here, but I get plenty.