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Antidote?
Quote from Jessica2 on April 9, 2023, 6:24 pmOk guys, I've been applying EPO on my face for about 4-5 nights now...I'm not even kidding there is already eyebrow growth where I haven't had to pluck in years, in between the two brows.
Just thought I'd point out the Linus Pauling institute/Oregon state study I linked earlier in this thread said that TOPICALLY applying these omega 6 EFA's was an effective way to normalize levels.
So those of you supplement weary, I think this is a good route to go. I'm honestly shocked at my eyebrow growth right now.
@pattycake Right when I swear off drinking you post this about red wine? 😆
@jessica2 that's amazing!
My mother would grind up different seeds and sprinkle on to yogurt with fruit. I ground up the flaxseeds and put in fish cakes/fritters. Lightly frying there was a slight risk of damaging the fats though.
@jessica2 I think you are in the U.S. - is that right? If you find walnuts that are not bitter, I would love to know where. The ones I bought this week were terribly bitter.
@lil-chick good call. I didn’t know that was problematic. They are raw, but some still look like burnt popcorn kernels.
@jessica2 thanks!
Nuts could be helpful after all. Who knew ?! An association at least with less NAFLD. https://onlinelibrary.wiley.com/doi/10.1111/liv.14164
@jessica2 How is the EPO testing going?
@jessica2 It's interesting that pumpkins, raspberries, blackcurrants, sunflower seeds, sesame seeds, almonds, hemp seeds and walnuts are all there. Probably with better liver health and less vitamin A we only need small amounts of these substances and they are in the seeds and nuts we could eat a few at a time or when in season. The oils being like a medicinal dose not normally available to us before we got better at pressing and extracting the oils. It must be quite difficult to extract blackcurrant and raspberry seeds and clean them to then make oil from. Ordinarily we wouldnt attempt that. Now we are often denied seeds in the grapes too.
Omega 7 is also interesting fat. Mostly in salt water fatty fish and macadamia nuts. I think I will start eating macadamia nuts again with my oatmeal. They are really good. But expensive.. 🙂
Triglyceride Cycling
Abstract
Triglyceride cycling is the process of continuous degradation and re-synthesis of triglyceride in cellular stores. We show in 3T3-L1 adipocytes that triglycerides are subject to rapid turnover and re-arrangement of fatty acids with an estimated half-life of 2–4 h. We develop a tracing technology that can simultaneously and quantitatively follow the metabolism of multiple fatty acids to study the triglyceride futile substrate cycle directly and with molecular species resolution. Our approach is based on alkyne fatty acid tracers and mass spectrometry. The triglyceride cycling is connected to modification of released fatty acids by elongation and desaturation. Through cycling and modification, saturated fatty acids are slowly converted to monounsaturated fatty acids, and linoleic acid to arachidonic acid. We conclude that triglyceride cycling renders stored fatty acids accessible for metabolic alteration. The overall process facilitates cellular adjustments to the stored fatty acid pool to meet changing needs of the cell.
Main
Triglyceride/fatty acid (TG/FA) cycling is the process of partial or complete degradation of stored fat to release free FAs that subsequently are used to resynthesize a new molecule of TG. On the one hand, it can take place on the whole body level, where free FAs released from adipose tissue can be re-esterified to TGs in the liver, leading to the organismal redistribution of stored energy1. On the other hand, it also takes place intracellularly, as a typical ‘futile’ substrate cycle that consumes energy without a net synthesis of biological material2.
In summary, these data show (1) a fast clearance of medium-chain FAs, (2) a slow desaturation of saturated FAs to produce equivalents of palmitoleic and oleic acid, and (3) a metabolism of linoleic acid equivalents towards arachidonic acid. All three processes are potentially beneficial to the cell or organism. Medium-chain FAs are useless or even potentially dangerous as membrane constituents. Their removal eliminates a potential problem and their conversion to long-chain monounsaturated FAs provides useful membrane building blocks. Palmitic acid is an abundant food constituent, but high concentrations of palmitate in lipids correlates with several adverse conditions22. Slow desaturation to beneficial monounsaturated FAs would reduce the danger of palmitate accumulation in stored TGs and prevent negative effects of released palmitate upon mobilization of stored fat. Arachidonate is an important FA with unique enzymatics in membrane lipid turnover23,24 and serves a key role as a precursor for eicosanoids in inflammatory signalling. Sustained levels of arachidonic acid are critical for mammalian life, as evidenced by many experimental studies in mice and by the absolute requirement of arachidonic acid in infant nutrition25. Conversion of the abundant linoleic acid to arachidonic acid in mammals is a complex multistep process active in hepatocytes26. Our data suggest that adipose tissue may support other organs in that process.
https://www.nature.com/articles/s42255-023-00769-z
It seems monosaturated oleic acid (olive oil as an example) is where the body wants lipocytes to rearrange towards. The question I had was "what kinds of poisons are released during this desaturation process?" and "does this cycling cause spikes in symptoms that could be prevented by consuming more lipocyte friendly mono-unsaturated fats vs saturated?". "Does the palmitic acid sequester toxins and release them more slowly as these fats proceed to become unsaturated?" This may explain why high animal fat can short term make ones feel better; slowing the detox until the unsaturation rate becomes unbearable.