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Extinguishing the theory of Vitamin-A toxicity in the west - Depletion of retinol levels as an immune response in infectious diseases and vaccination
How is it known that Vitamin A is released from the liver to fight infections? I looked at your substack but didn't find an answer to that.
Quote from Eio on July 2, 2025, 6:54 amHow is it known that Vitamin A is released from the liver to fight infections? I looked at your substack but didn't find an answer to that.
Read the studies in the article. Then you do some of your own research and read more studies on the subject.
Hmm, I've often wondered about all these things. I too believe that VA is a weapon, but one in which you can die from the friendly fire. Or be sick enough to want to die (black humor there, but really though).
In my hypothesis, when you get a vax it's kind of random where the bad stuff ends up. The body sees it there, goes into alert mode, and shuttles VA over (as it would do with a regular infection). So, for instance, in my loved-one's case the vax (unluckily) went to his pancreas, the immune system sent a boat-load of VA there (at the time he was drinking blenders full of eggs), the surface of the pancreas got "eczema" and next thing you know his islet cells aren't working and the teen is drinking soda all day long to quench his thirst and has turned into skeleton because he can't make insulin. (type-1 diabetes ie. "juvenile onset")
I've also seen there are "acute" symptoms of poisoning when you have had too much VA in the last day or so (such as vomiting and head pressure, very much like a hangover)... This can be fatal (for instance arctic explorers consuming polar-bear liver) and "long term" symptoms (such as eczema and gum disease) when you have had too much VA over too long of a time and the surfaces of your body get created improperly because the VA is hanging around being the pesky toxin that it is.
Unlike some here I actually do worry that someone might end up with an empty quiver of VA arrows over time. But I probably will never get there, given I spent an entire life with "acute" symptoms and "long term symptoms" from age of about 12 until I read Grant's book at 55. I don't think I'll ever run out.
I think the "overflowing cup" metaphor that What-Is-Aging gave is an especially good one. If you feel you have an "overactive immune system" you probably have an overflowing cup of VA. Cutting down that cup to where it isn't spilling over will be much more comfortable and healthful.
I also think we need to consider the obesity epidemic in all of this. I definitely believe that some people's bodies are wise enough to create fat in which to store excesses of VA. (For good or bad, my body doesn't seem to do this very well). This points to a problem in general of too much VA being ingested by our culture.
I've always espoused moderation. My diet has always only been low-moderate and not "prison food diet". And I would be especially moderate when raising children. I would put them on a diet much like his or her personal ancestors ate during growth. One that seemed successful for that ancestor. I've studied my grandparents (born in 1910's) and I do know that their VA intake was lower than what I was doing. It was quite bland and repetitive and yet created people who got close to 100 years of age. My progress has been steady but at the slow pace of glaciers.
https://ggenereux.blog/discussion/topic/va-as-a-weapon/
Have not reviewed this thread lately, but maybe it has other people's opinions on the subject.
@lil-chick "Unlike some here I actually do worry that someone might end up with an empty quiver of VA arrows over time. "
that's what I am thinking as well. But if you think it is not your case. I think it is not mine as well because I think I ingested in that 10 or so year period probably twice as much as you lol. Not to mention I was taking accutane as well. But only small dose.. Have you ever done serum vitamin A test? I wish I did. Because to really understand what is going on we need more tests to see some pattern. If it's going down with time or zig zag or whatever.. Now if I do my first test I am scared that I will see low number and I will start eating a lot of liver lol. 😀
Right now I have an infection and the day before the infection arrived (when it was catching but unable to be seen or felt by me) I had the hungover, VA-overload feeling (such as headache). This seems to always happen when I have an infection (last time it was swimmers ear, this time impetiego).
I have been low-moderate for 6 years now including the covid years. I did not catch covid although it was in my house 3 times and I am of the age that they were saying the disease could be dangerous.
I think one of the things Grant says, when people ask him about this topic, (ie. will your lack of VA cause you to not be able to fight infection?) is that he doesn't seem to get sick anymore.
I seem to be more apt to get infections when I get "run down". My current infection took hold after a week of travel (and I have travel phobia) and not sleeping well for an entire week.
One of my guesses may be that it is quite "expensive" (nutritional status-wise and energy-wise) for the body to keep overloads of VA around. You might be able to fight things off better when not burdened. You might not need weapons so often?
You can't just extinguish the hypervitamosis A concept. Look at the Wikipedia page on it. It's a known thing.
A lifetime of motion sickness and chronic vomiting and insomnia has led to my travel "phobia". I like to joke that my dread of travel is not actually a phobia because phobias are *irrational fears*, while my fear of travel is quite rational. Travel has always made me suffer even more than usual, LOL. Dizziness (vertigo, ie inner ear issues) are a symptom of hypervitaminosis A, as per Wikipedia) . Low level vertigo leads to motion sickness. I often think that sometimes I am the "poster child" for VA toxicity LOL. When I saw the list of symptoms (on Wikipedia) my entire life suddenly made sense. After reducing my VA burden I can now travel, but the fear remains.
Doctors have never been able to help me because they were blind to the topic. IMO it is a gaping hole in current practice, and an embarrassment to the field.
@lil-chick My parents never had a car, but when we were riding to soccer matches as a kids and I was very sick to my stomach so many times.. I also puked in a car once. It was road up and down. I was also puking after ride on small chain carousel. I remember all that like it was yesterday it's like 35 years lol.. I don't even have drivers licence for that reason. I can ride a bike like psycho, but put me in a car and I feel sick very fast, my ears get "plugged" etc.. They say when you drive the car you don't get that sick feeling, but I don't know. I never felt comfortable driving a car and I was always afraid that I will cause some accident and kill someone. I even had a lot of dreams where I was driving all kinds of vehicles always crashing. I mean if that is not a sign that I shouldn't drive than I don't know what is hehe..
Quote from Tobias on July 2, 2025, 3:21 amYou have to look at the broader picture, the one I explain in the article.
"The large amount of viral RNA and consequent overwhelming immune stimulation will cause increased RA consumption, and with the time, depletion of retinol reserves in the body [20], [21]. " https://www.sciencedirect.com/science/article/pii/S0898656821002102?via%3Dihub
It is a combination of accute toxicity due to unatural triggers because of vaccines that trigger multiple infections (spike proteins) ultimately depleting the retinol reserves that lead to deficiancy.
We know that retinol is used to fight infections, the vaccines disrupts the retinoid singaling causing cytokain storms that leads to Toxicity, but not chronic. As multiple infections caused by the cytokain storms i.e the immunesystem attacking the body cells leads to a depletion.
When breaking this down you have to take all the information - in the different studies into consideration.
Once again, I don't see any evidence. The paper you cite is another opinion piece:
A novel HYPOTHESIS for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder
The full texts of references [20] and [21] don't even contain the word retinol! How is this evidence of retinol depletion?
Here are reference [20] and [21]'s abstracts. They are biochemistry papers which study retinoic acid pathways. They are not papers which demonstrate retinol depletion.
[20]: Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs) constitute distinct families of pattern-recognition receptors that sense nucleic acids derived from viruses and trigger antiviral innate immune responses. TLR3, TLR7, and TLR9 are membrane proteins localized to the endosome that recognize viral double-stranded RNA, single-stranded RNA, and DNA, respectively, while RLRs, including RIG-I, Mda5, and LGP2, are cytoplasmic proteins that recognize viral RNA. Upon recognition of these nucleic acid species, TLRs and RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways culminating in activation of NF-κB, MAP kinases, and IRFs that control the transcription of genes encoding type I interferon and other inflammatory cytokines, which are important for eliminating viruses. Here, we review recent insights into the signaling pathways initiated by TLR and RLR and their roles in innate and adaptive immune responses.
[21]: Innate immunity is the first line of defense against invading pathogens. Rapid and efficient detection of pathogen-associated molecular patterns via pattern-recognition receptors is essential for the host to mount defensive and protective responses. Retinoic acid-inducible gene-I (RIG-I) is critical in triggering antiviral and inflammatory responses for the control of viral replication in response to cytoplasmic virus-specific RNA structures. Upon viral RNA recognition, RIG-I recruits the mitochondrial adaptor protein mitochondrial antiviral signaling protein, which leads to a signaling cascade that coordinates the induction of type I interferons (IFNs), as well as a large variety of antiviral interferon-stimulated genes. The RIG-I activation is tightly regulated via various posttranslational modifications for the prevention of aberrant innate immune signaling. By contrast, viruses have evolved mechanisms of evasion, such as sequestrating viral structures from RIG-I detections and targeting receptor or signaling molecules for degradation. These virus–host interactions have broadened our understanding of viral pathogenesis and provided insights into the function of the RIG-I pathway. In this review, we summarize the recent advances regarding RIG-I pathogen recognition and signaling transduction, cell-intrinsic control of RIG-I activation, and the viral antagonism of RIG-I signaling.
If you're using AI to find literature, that's fine, but you need to actually read the papers. AI hallucinates.
Quote from Tobias on July 2, 2025, 5:10 amYou do realise that you embraced this theory off a book that included no mention whatsoever of retinol depletion during infection and inflammation as part of a key factor for immune response? The explanation you got was "once accumulated you can not get rid of it".
I just wrote you a scientific article explaining the complexity of vitamin a, balancing both the risks and the benefits.
You might get by several years if your retinol storage level is maxed out or even overloaded. But once you get sick - infection or retonic acid signaling system activation from vaccines - you might not get by so well if you continue in the same tracks. It is also proven that retinol is essential for brain growth - hippocampus and nervous system. I would not paint this topic in either black or white - which is why I wrote this article. It's up to you if you want to listen and learn from it.
Best.
"Scientific article" is a bit much, don't you think? 😉 I still haven't seen any evidence, just references to opinion pieces. I had to look up the literature for retinol depletion myself, when it should have been in the article.