Quote from Jiří on July 13, 2020, 1:20 am

@r-2 bro this is little too crazy.. 🙂 Nobody can eat 5 eggs a day because you think you have selenium toxicity(which I think is not true most likely..) ?  The body is using good amount of selenium all the time for all kinds of functions especially during high stress. You will not get toxic from eggs omg. There is A LOT of people eating A LOT of eggs every day for decades with no issues. In your second post you are mixing so many things together. Yes people in western world eat too much calories. Especially "empty and wrong" calories in form of flour, vegetable oils, sugar. They are toxic in some micronutrients and deficient in others etc.. You simply need to eat how much you need to live YOUR life. That makes sense. 30 yo male with crazy hard manual labor job. Who wants to build muscles and do sports will have completely different diet needs than "office rat" that is burning almost no calories.. Now that is for people that don't have any more serious metabolic issues from some toxicity etc.. They can just eat less or eat more and be ok. People like you and me have issues that can't be fixed just by calories. Like increase calories/carbs so metabolism will speed up etc.. If there is some serious imbalance. Toxicity, deficiency or the body simply can't handle more oxidative stress than yes more calories will hurt you not help you. 10 years back if I was eating more I would get just more glycogen in the muscles, higher body temperature etc. how it should be. Now if I increase carbs/calories I will get just symptoms of inflammation, high oxidative stress. So I can't handle other types of stress like sunbathing etc.. So now I feel like I also can't handle 3000kcal+ every day. I feel it. It naturaly goes down to like 2500kcal. But once everything start working as it should. Healthy people eat a lot. Look at diets of healthy and active people around 20-30yo.. 3-4000kcal like nothing. Athletes 4-5000 kcal is completely normal without any force feeding or something. Simply the best approach is to listening your body for sure. It doesn't matter what someone says that you should eat. In general the more healthy you are and the more active you are you will eat more. THe less healthy you are and the less active you are your apetite will go down.. It is completely normal and natural. So the same person can have ideal intake 2000kcal and year later 4500kcal.. Both will be optimal for their needs at that time..

Quote from leap7 on December 14, 2020, 12:58 am

What do you think about supplementing with beta glucan? Does anyone have any experience with it? I found out about the Transfer Point beta glucan supplement from Garrett's forum. I am thinking about trying it, since I think I have narrowed down beta glucan as a factor that is helpful for my muscles. I don't want to consume oats or barley because of lutein, and I can only eat so many mushrooms... 

Quote from Jiří on March 21, 2021, 5:37 am

Quote from leap7 on December 14, 2020, 12:58 am

What do you think about supplementing with beta glucan? Does anyone have any experience with it? I found out about the Transfer Point beta glucan supplement from Garrett's forum. I am thinking about trying it, since I think I have narrowed down beta glucan as a factor that is helpful for my muscles. I don't want to consume oats or barley because of lutein, and I can only eat so many mushrooms... 

I started eating gluten free oats again. I feel like without significant source of soluble fiber(beta glucan as the ideal one) in my diet I will be detoxing forever and oats are by far the best source of it.. 100g per day is more than enough and I don't see how some lutein from 100g of oats can be more negative than having that much extra beta glucan in the diet to support detoxification... It's funny, but when I look at all kinds of diets it seems that average fitness/bodybuidling diet has the best balance. Lean meats, low fat dairy, eggs, white rice, oats, bananas, some vegetables here and there like broccoli, green beans, some added fats from olive oil, avocado... Plenty of protein, low fructose, low PUFA, low vit A.. No wonder bodybuilders who were following diet like that for most of their life look really good even in their 60s, 70s... 

Quote from rockarolla on March 21, 2021, 9:41 am

Quote from Jiří on March 21, 2021, 5:37 am

Quote from leap7 on December 14, 2020, 12:58 am

What do you think about supplementing with beta glucan? Does anyone have any experience with it? I found out about the Transfer Point beta glucan supplement from Garrett's forum. I am thinking about trying it, since I think I have narrowed down beta glucan as a factor that is helpful for my muscles. I don't want to consume oats or barley because of lutein, and I can only eat so many mushrooms... 

I started eating gluten free oats again. I feel like without significant source of soluble fiber(beta glucan as the ideal one) in my diet I will be detoxing forever and oats are by far the best source of it.. 100g per day is more than enough and I don't see how some lutein from 100g of oats can be more negative than having that much extra beta glucan in the diet to support detoxification... It's funny, but when I look at all kinds of diets it seems that average fitness/bodybuidling diet has the best balance. Lean meats, low fat dairy, eggs, white rice, oats, bananas, some vegetables here and there like broccoli, green beans, some added fats from olive oil, avocado... Plenty of protein, low fructose, low PUFA, low vit A.. No wonder bodybuilders who were following diet like that for most of their life look really good even in their 60s, 70s... 

@jiri What are your main detox symptoms? Are they mostly generic like fatigue or more specific, like pains in some parts of the body?

Quote from Jiří on March 21, 2021, 9:54 am

@rockarolla It's up and down all the time with energy, dry skin etc.. I am not saying it must be just vit A.. But I know for sure that when I eat low fiber just meats, rice etc.. The body simply can't detox.. Now I started taking hydrochloric acid as well. That is also source of all kinds of symptoms..

Quote from rockarolla on March 21, 2021, 10:01 am

Quote from Jiří on March 21, 2021, 9:54 am

@rockarolla It's up and down all the time with energy, dry skin etc.. I am not saying it must be just vit A.. But I know for sure that when I eat low fiber just meats, rice etc.. The body simply can't detox.. Now I started taking hydrochloric acid as well. That is also source of all kinds of symptoms..

There is a paper I recently stumbled on talking about increasing of energy in people with auto immune diagnose with the help of VA.

So to look at this other way the absence of A could bring a lot of fatigue, similar thing happens with vit D "deficiency" very often. I think when the body systems are kicking in to repair the damage, etc they are very hungry for nutrients like proteins and glucose and this, in turn, puts the body into the [chronically] fatigue state(no free energy to spare).

 

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[2016] Effect of Vitamin A Supplementation on fatigue and depression in Multiple Sclerosis patients: A Double-Blind Placebo-Controlled Clinical Trial
https://pubmed.ncbi.nlm.nih.gov/26996107/

Decreasing the population and activation of inflammatory T helper cells in multiple sclerosis (MS) patients using vitamin A derivatives (retinoic acids) has been well documented. The present study determined the effect of vitamin A supplementation on psychiatric signs in MS patients. The subjects were 101 relapsing-remitting MS patients enrolled in a placebo-controlled randomized clinical trial. The treatment group was administered 25000 IU/d retinyl palmitate (RP) for 6 months followed by 10000 IU/d RP for another 6 months. The results for baseline characteristics, modified fatigue impact scale and Beck Depression Inventory-II were recorded at the beginning and end of the one-year study. The non-normal distribution data was compared between groups using a nonparametric test and normal distribution data was analyzed using a parametric test. (ClinicalTrials.gov Identifiers: NCT01417273). The results showed significant improvement in the treatment group for fatigue (p=0.004) and depression (p=0.01). Vitamin A supplementation helped during interferon therapy in the treatment process and improved psychiatric outcomes for anti-inflammatory mechanisms.
...
Studies have indicated that retinoic acids (RAs) suppress the production and proliferation of pathogenic T cells and induce production of regulatory cells from naive T cells.
2-4 Qu et al.4 reported that RAs can modulate disease progression in relapsing experimental allergic encephalomyelitis. They showed that Etretinate (synthetic RA) increases the effect of interferon beta on the function of suppressor T cells and thereby
modulates MS activity.

Human studies have shown that supplementation with 25000 IU/d vitamin A elevated the RAs concentration in blood. Binding RAs
to retinoic acid receptors (RARs) on peripheral blood mononuclear cells activates a cascade of intracellular pathways stimulating an anti-inflammatory effect by alteration in the expression of some related genes.

RA can also induce neuroregeneration and reduce the psychiatric diseases such as long-term depression.
Psychiatric signs including fatigue and depression are common manifestations of an inflammatory process in MS patients.

The authors have previously demonstrated that RAs down-regulate the inflammatory cytokine genes.

The present study demonstrates that vitamin A as an immune modulator can improve psychiatric signs in MS.

No study has demonstrated the effectiveness of vitamin A on the clinical problems of fatigue and depression in MS patients yet. This randomized trial study was designed with a large sample size (101 patients), long-term supplementation (1 yr), critical inclusion criteria, and high dose RP (25000 IU/d) to identify the potential effects of vitamin A on some clinical signs in MS patients.

Confounding factors were considered by measurement of baseline characteristics, psychosocial stressors and dietary intake of vitamin A. There were no significant differences in confounding factors between groups (Tables 1, 3 and 4). In the present study, we used two validated questionnaires, the MFIS and BID-II, for detection of fatigue and depression in MS patients. It was found that scores for depression, total fatigue and the three subscales of fatigue (physical, cognitive and psychosocial) improved significantly with consumption of vitamin A
(Table 2).

Fatigue is a major and disabling problem that affects the quality of life of MS patients. The mechanism of fatigue and its relationship with other clinical signs in MS is not well known. The unknown pathogenesis of fatigue in MS makes it difficult to treat.

Comi et al.20 showed that fatigue correlates with mood disorders in MS patients. They also noticed that the existence of inflammatory cytokines played a major role in the pathogenesis of fatigue. This finding was also reported by Flachenecker et al.21 MS patients encounter with a higher risk of depression than healthy individuals.

Several mechanisms have been reported for the pathogenesis of depression in these patients. Immune dysfunction, level of disability and psychosocial stressors relate to depression in MS.

Few studies have been focused on the evaluation of vitamin A derivatives or RAs on clinical signs in MS patients. To the best of our knowledge, one previous study administered etretinate (synthetic RA) to MS patients for 6 mo. Qu et al. detected many serious side effects that masked the probable positive effects of etretinate on clinical manifestations and detected no significant differences in fatigue and depression in treated patients.

The present study treated the patients with RP[Retinyl palmitate] instead of RA to avoid the serious side effects of RA.

The preferred mechanism for improvement of fatigue and depression in MS is the effect of vitamin A on the level of inflammatory cytokines

Vitamin A converts to RA in response to liver regulatory functions and the level of circulating RAs will increase.
One study showed that, after 6 months of supplementation with 25000 IU/d RP, the level of circulating RAs increased to 3-4 ng/dl.

RAs in the blood stream will bind to their receptors on peripheral blood mononuclear cells including RARalpha and gamma effectively and functionally. Previous cellular and molecular assessments by the authors have shown that 25000 IU/d RP inhibits the proliferation of inflammatory T helper cells downregulates gene expression of inflammatory cytokines and their transcription factors9 and also altered the expression levels of RAR-alpha and gamma genes in MS patients.

Several studies have revealed that RAs alter the Th1/Th2 balance towards Th2, increase production of Foxp3+ T cells instead of Th17 from naive T cells, and regulate the immune response in MS patients. This regulation may result to ameliorate the signs of fatigue and depression in MS patients.

None of the patients was excluded from the study, because of adverse effects of 25000 IU/d RP administration. Moreover, no pathological changes in lipid profile or liver laboratory tests were found following one year of intervention. Our previous reports also indicated no adverse effects of RP[Retinyl palmitate] (25000 IU/d) supplementation in MS patients.

Lacking the toxicity of above mentioned dose of RP for 1 yr has been shown previously.

It is recommended to confirm our study using different types of questionnaires for measuring fatigue and quality of life.

Finally, we found that supplementing MS patients with RP alongside the interferon leads to promising results without complications. The results demonstrated that vitamin A improves fatigue and depression in MS patients through the modulation of inflammatory conditions.

Quote from Jiří on March 21, 2021, 11:12 am

@rockarolla I understand this very well that it's not always a bad thing when you don't feel good. It's much worse to keep "fake energy" with all kinds of things and than completely crush with cancer or something.. That's why I will not take anything that can trick my body that I have energy.. Now I am not talking about sugar. That is macronutrient in my eyes, but some people thing that sugars are like drugs which is crazy heh.. I need to do another hair test to see where I am. What minerals I should take.. Also huge problem is to know how much and which B vitamins should I take.. Hard to tell if I am low in things like B1,B2 or I feel like shit because I take too much or bad form.. I also started eating ground pork instead of ground beef.. It has much better mineral and vitamin profile. Just lower zinc content, but I take it with supplement anyway so that's not a problem.. I think it was a mistake to eat so much red meat at the beginning. Too much iron.. Btw if somebody is intersted in HCL. https://health-parameters.com/posts/hydrochloric-acid-therapy-hcl-therapy/ many people take betain HCL for digestion. I take hydrochloric acid in liquid form.. 3,5% concentration 15 drops into gelatin capsule with last bite of food.. Great for digestion and also people can take it on empty stomach with water. So it goes to lymphatic system and really cleanse the body.. I was taking it already in 2018 and look what was coming out in my urine..

Quote from Mattia on April 4, 2021, 8:20 am

@jiri

Very interesting, I might try HCL therapy in the near future.
I have been taking betain HCL before but maybe HCL is more potent.

Quote from Jiří on April 4, 2021, 8:37 am

@mattia Most importantly it is dirt cheap. Works really good especially for digesting meat.. Older people have very low stomach acid production. That's why they eat less and less meat..