I needed to disable self sign-ups because I’ve been getting too many spam-type accounts. Thanks.
NAD deficiency - is this a major issue for vA toxicity/detox?
@jessica2
No worries, I like it a lot, one of its main perks, is that it improves the cellular oxidation of sugar, so it feels great with things like orange juice. As I mentioned in my previous comment, oxidation of sugar is metabolically efficient and spares oxygen consumption. The methylene blue gives me a very nourishing oxygenated feeling in my brain, that feels really good. Niacinamide (non flush) synergies really well with the MB. I’m now finding this Sporebiotic I’ve started also has this oxygen sparing effect and works well with the other things I’m taking.
I think the most important thing about MB is that it’s an electron donor capable of bypassing Complex I and II. If Complex I is inhibited then the NADH:NAD+ redox is inhibited which causes a NAD+ insufficiency and an elevation of NADH. Which leads to an inability to metabolise and detox Vit A through ALDH being down. Glutamate catabolism is also impaired when Complex I is impaired. An immune response to pathogens, heavy metal toxicity, aging, oxidative stress and certain micronutrient deficiencies can all impair Complex I.
Interesting theory about the colours, my mum is also an artist.
MB is anticholinergic, so in the last week I’m finding that phosphatidylcholine works well with it and is needed at times with the MB, also provides additional liver support.
MB is an oxidiser so it shares that similarity with MMS that certain people were taking, however MB has far more research and studies on it than MMS does. I’m not entirely sure but I don’t think MMS possesses the same mitochondrial benefits as methylene blue does. Also the thought of drinking something that smells like chlorine is sickening and instinctively doesn’t feel right to me so that’s partly why I stayed well away from it.
MB can be cytotoxic so I sometimes take antioxidants like EGCG, Vit E , whole food Vit C to counter the cytotoxic effects.
MB For Covid
Rising use of methylene blue in India as COVID-19 prevention/treatment
MB for Alzheimer’s
Niacinamide and MB increase estrogen deactivation
MB Redox Potential
MB reverses Fatty liver
https://raypeatforum.com/community/threads/methylene-blue-mb-reverses-fatty-liver-disease.6701/
MB Uncouples respiration
https://raypeatforum.com/community/threads/methylene-blue-mb-uncouples-respiration.6212/
@inger I have white hairs too. White, not grey. I also have a mole on my face with a hair in it, sometines it grows out dark, sometimes white, sometimes it is half/half until I pluck it. I had some whites growing in dark when I did Grant Style some years back, but my whites has for sure increased from some to a lot, most on the right side of my head, same side where I have had än acne breakout (Mainly at one spot) since like last october or so. For me it is a sign stuff is going on for sure. But what precisely it is I do not know. dad got less grey when adopting a more plant based diet eating more vegetable oils and dropping dairy and animal fats and I never really got that either. I'd love to understand the mechanism too. Would love to get rid of those whites 🤣
Here an interesting article on High-dose Niacin potentially reducing NAFLD,
https://researchfeatures.com/high-dose-niacin-promising-treatment-non-alcoholic-fatty-liver-disease/
You gotta love this part:
We believe that investment in a Phase 2 trial, if successful, could generate a valuation of $5-10 billion for the combination therapy.
and
Subsequent testing of this idea confirmed this in preclinical and preliminary clinical trial data, warranting a phase 2 trial program especially with another patented drug in development to enhance efficacy.
We demonstrate that loss of Nampt increases susceptibility toward damage from MCD (methionine and choline deficient) diet, leading to an increase in plasma ALT activity and a decrease in lean mass. Nicotinamide phosphoribosyltransferase (NAMPT) converts nicotinamide to NAD+. Our data suggest a critical threshold level of hepatic NAD+ that determines the predisposition to liver injury and supports that NAD+ precursor supplementation can prevent liver injury and nonalcoholic fatty liver disease progression. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648833/?fbclid=IwAR2116PGeKlpesJDdQV9eUwREOUxGZpkYJJQvYSp3hqhB2IlaDB_euyLCWw
Kynurenine pathway is upregulated by methyl-deficient diet (choline) and changes are averted by probiotics. https://pubmed.ncbi.nlm.nih.gov/33686786/
@alexm thank you for your input into this as your ideas have really moved my thinking along.
I’m not doing much research atm as my seizures are not helped by overthinking as it depletes NAD and increases glutamate. Excess glutamate is my final trigger I think, but this excess rests on a lot of other dysfunction. High glutamate foods and anything else that increases excititoxicity must be avoided while I sort out the underlying issues driving my metabolism this way.
I think it all comes back to Robert Naviaux’s work on the cell danger response (CDR). ‘Mitochondria are at the hub of metabolism’. When mitochondria get overwhelmed by stress, toxicity, infection etc they stop doing their main task, which is producing energy, and start doing their other task which is producing the CDR. This means metabolism stops working well. NAD isn’t recycled properly. The workarounds get used. Workarounds often have toxic side effects. VA detox slows down and aldehydes build up which deplete B1 and B6. Vicious cycles develop.
Stress, vA toxicity and detox, lack of choline are all drivers of the CDR. This needs to be calmed down as a priority and for some people psychological modalities are the way that it needs to be done. Doing the vA detox in a stressed state is really not a good idea. Add in low choline as well and you’re on the road to disaster. CDR gets worse. Metabolism more dysfunctional. Deficiencies of NAD, B1, B6 etc lead to a whole big mess. In me it’s resulted in glutamate excess and an excitotoxic state (other factors involved) but in others the result will be different. Need to calm down the CDR as a priority.
@jaj Np do you still eat the biona canned chickpeas as I remember you mentioned you ate them ages ago. I know they are laden with glyphosate in my experience from eating them in the past. Eating glyphosate containing foods gives me high glutamate symptoms since going low VA. Glyphosate can cause major glutamate issues as it chelates copper, magnesium, sulfur and manganese. Canned foods will also have metals like aluminium that leach into the food and that causes me additional neurotransmitter issues. Then as Stephanie Seneff says (if I remember correctly) glyphosate and aluminium pair up together and cause havoc in conditions like autism. There was a major difference when I switched from canned to non canned for beans.
I will share some other tips that have helped me in the last year that might help you or others on this forum:
Don’t cook with tap water, use volvic water or RO water to cook if you can instead even though it’s more expensive. When showering just make sure you don’t get the water in your eyes as it’s harmful and will cause you issues. So keep your eyes closed and push the water down away from your eyes when washing your hair and face. Also when rubbing you eyes to clear sleep dust in the mornings make sure your hands are washed first, likewise if you are someone who picks their nose or needs to clear out what’s in their nose, make sure hands are cleaned first. Otherwise without clean hands you run the risk of getting bacteria, fungi, chemicals, pesticides inside your body disrupting minerals, mineral transport, NAD synthesis etc.
Dish sponges harbor bacteria and rancid oils like crazy so I always use my own dish sponge and keep it clean and replace regularly. When I’ve used certain sponges in places I’ve stayed it’s caused high glutamate symptoms too, as while you are using the sponge to clean dishes, some of the bacteria, fungi in the sponge will get inside your nails as you’re cleaning. Using rubber gloves can also be another option.
You may have furniture, clothing , dish cloths that have pesticide residues on them that could be another thing that may be affecting you daily unknowingly. For laundry detergent use a non bio scent free one.
If you live in London try get fruit and veg from wholefoods market or planet organic, a lot of the UK grown organic veg from Sainsbury’s and Waitrose have pesticides still. I’ve found organic fruit and veg imported from European countries is mostly pesticide free where as a lot of supermarket organic UK grown food isn’t. The Amisa brand for organic Oats are the only organic oats I found that didn’t have pesticides and I do well with them.
Maybe this stuff sounds extreme but for people who have more toxicity won’t be able to deal with these things as well. Also I actually think a lot of these things that I’ve mentioned above, are affecting most people everyday, unknown to them. I got back from Costa Rica a few weeks ago and I didn’t see one healthy looking person in London for days… Everyone looked ill, anxious, stressed or toxic. People are really not healthy here and walk around like zombies. I do think the long cold winter also plays a major part in that on top of all the things I mentioned above, plus the 3 years of covid hysteria and possibly Covid vaccines. Then also when you cut out toxic foods, water and products, balance minerals, detox the body properly (like I did for 6 months with daily coffee enemas and such), you start to see how ill, dysfunctional and stressed everyone else is compared to you.
(Edited typos)
I’m using silicol gel which acts as a binder that binds to acetaldehyde, endotoxins, salts of heavy metals. It’s silicon dioxide which isn’t bioavailable but works well as binder for the things mentioned above.
And you wonder how the Vit A toxicity issue starts in the first place:
ChatGPT generated list of microbes that make ethanol / acetaldehyde:
Escherichia coli
Klebsiella pneumoniae
Enterococcus faecalis
Enterococcus faecium
Bacteroides fragilis
Candida albicans
Saccharomyces cerevisiae
Streptococcus bovis
Lactobacillus brevis
Lactobacillus fermentum
Lactobacillus pentosus
Lactobacillus plantarum
Clostridium perfringens
Clostridium difficile
Clostridium histolyticum
Fusobacterium spp.
Veillonella spp.
Eubacterium spp.
Peptostreptococcus spp.
Propionibacterium spp.
Acetobacter spp.
Acetobacterium spp.
Butyrivibrio spp.
Megasphaera elsdenii
Ruminococcus spp.
Anaerostipes spp.
Coprococcus spp.
Roseburia spp.
Faecalibacterium spp.
Eubacterium limosum
Blautia spp.
Anaerotruncus colihominis
Eggerthella lenta
Lachnospira spp.
Bifidobacterium spp.
Peptoclostridium difficile
Streptococcus thermophilus
Enterobacter spp.
Proteus spp.
Pseudomonas spp.
Staphylococcus spp.
Streptococcus spp.
Veillonella dispar
Akkermansia muciniphila
Desulfovibrio spp.
Methanobrevibacter smithii
Methanosphaera stadtmanae
Methanomassiliicoccus luminyensis
Methanobacteriales
Methanomicrobiales.
Parabacteroides spp.
Alistipes spp.
Butyricimonas spp.
Anaerostipes hadrus
Oscillibacter spp.
Ruminococcus gnavus
Ruminococcus torques
Subdoligranulum spp.
Turicibacter spp.
Blautia obeum
Lachnobacterium bovis
Ruminococcaceae bacterium D16
Ruminococcaceae bacterium A1
Ruminococcaceae bacterium CPB6
Phascolarctobacterium spp.
Clostridium bolteae
Clostridium ramosum
Clostridium saccharobutylicum
Collinsella aerofaciens.
@jiri It’s called silicol gel but I think it’s the same thing, why do they want to ban it? I’m using it as a binder for now and I like it but it will do nothing about raising my silicon levels so I plan to switch to a bioavaliable form soon. I also plan to do an Oligoscan mineral and metals test to see my silicon levels and other things.
There’s this researcher who made a protocol for reverse engineering CFS, long Covid and lots of other chronic diseases.
He found that nearly all chronically ill people show a silicon deficiency in oligoscan mineral tests. He also found HTMA shows functional deficiencies eg you may have enough of a mineral that shows low on HTMA but your body is just not using it. Where as oligoscan shows true deficiencies and measures the mineral levels inside your working cells.
“Silicon - with that so low, the system cannot escape hypoxic signalling which then models for latent virus reactivation causing all sorts of havoc including keeping the immune system stuck on. Also this cripples tissue repair so among other things mucous membranes cannot keep up with continuous pathogen insult -> leaky gut, dysbiosis, pain, MCAS, etc etc“
“The issue is mucosal pathogens making acetaldehyde (draining silicon), breaking through a barrier that can’t be maintained (collagen synthesis, low silicon->mag), which gets further damaged by IFN-gamma activity / collateral oxidative damage (low vitamin C, clotting). The microbiome is the frontline defence against this. If you can deal with the microbiome sufficiently and eat well enough, you could remove the acetaldehyde issues, regain silicon, collagen synthesis and break out of the loop.”
This sounds like further proof of the benefits of silicon supplementation.
I'd be careful with silicon dioxide. It's a nanoparticle that can pass through the intestinal barrier and into cells (more on nanoparticles: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC544578/). There is an extensive thread about silicon dioxide on the Ray Peat forum: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC544578/