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nerve pain
Quote from Jenny on June 28, 2023, 6:00 amInteresting. This is all a new concept to me - that I’ve got v. low B6 particularly in brain - so I’m currently thinking about it. Meri Arthur will be doing some more of her excellent videos at some point (YouTube ‘weak therefore strong’) and posts on FB. This idea is entirely based in her work and the private chats we’ve had.
There are a number of boxes that this theory ticks. A number of perplexing questions that I’ve never answered. When a theory ticks a lot of boxes then it needs taking seriously. The vA toxicity theory did. The choline deficiency theory did. The NAD deficiency theory did. Now this B6 deficiency theory has given me a number of light bulb moments. They are all theories of course, but ones that seem to hold weight, at least for me.
B6 is also depleted by pyroluria, which I tested positive for in 2015. However, I’ve addressed this. It did not seem possible that I was still B6 deficient. I knew aldehydes depleted B6 and have long thought my issue is slow ALDHs. However, I did not know that if ALDH7A1 was impacted the result was products from lysine metabolism such as P6C that inactivate B6. A triple whammy - depleting all the B6. This can cause low folate, and follinic acid is on the treatment plan for this genetic syndrome (B6 deficiency epilepsy). Low B6 and folate are the result of slow ALDH7A1 but they then become causes of this, through sulphur and methylation issues. Most chronic health issues involve ever worsening vicious cycles. I’m seeing a lot. Knowing how to break them at multiple points is the best way to health I think. If you don’t know what they are though, you can’t break them.
This is just so fascinating, Jenny! What I’ve highlighted in bold is a topic in need of its own thread, really. I was just talking to another low-VAer about this, who has genetic metabolic limitations also, and it made me wonder if most of us dealing with chronic hypervitaminosis A do too? Though there will be differences in what exactly is the problem, of course.
I’ve been trying to fine-tune my diet the past couple of months, and right now have settled on a combination of foods super high in B6...the plan is to continue with this combination for a month to see what happens, then adjust. I was trying to go for less methionine, more glycine, but it turns out I have also inadvertently chosen some of the foods highest in arginine relative lysine as my staples (cabbage, dates, flaxseed, hemp hearts, lentils)... So I’m getting roughly double the amount of arginine to lysine.
I have no idea what my genetic weaknesses are (perhaps ours are quite different—I should get tested, I suppose), but this makes me curious so I’m going to lean into this coincidence.
How many grams of lycine would you consider a “low” daily intake, @jaj?
The condensed tannins also aggregate with bile salts and reduce fat absorption. Remember vA world being obsessed with reabsorption of fat. Well berries can reduce the absorption. Those darned polyphenols 🙂 Characterizing the Interactions of Dietary Condensed Tannins with Bile Salts | Journal of Agricultural and Food Chemistry (acs.org)
The problem with blueberries at least is thiaminase, in my case because of my thiamine deficiency I stopped.
- Bacopa I find dissipates the depression of the detox. Not a small thing!!! It must contain some lutein and beta carotene though, and I have no idea how to calculate if it would be significant for a 1500 mg daily supplementation.
Apparently it is helpful for ADD, too... Maybe I should try it? 😅
https://draxe.com/nutrition/bacopa/
How long have you been taking it, @ourania? It’s supposed to enhance acetylcholine.
From the article above:
“While little human research has been done, there is a plethora of research in animals that suggests bacopa may be a natural epilepsy treatment. These research studies find that treatment with bacopa regulates gene expression, helps correct faulty reception of brain cells and helps increase GABA responses.
All of these results are a good sign that the cognitive impairment and seizure activity caused by epilepsy could potentially be relieved with bacopa.“
We took Bacopa more than 20 years ago when we realized we were being MSG poisoned. I notice that there is a link vA-glutamate in some way. Started taking it again 5 days ago because I was trying to help my memory as I am learning a new language. I am doing this exercise on my whole body vibration machine that really helps memory (or rather dissipates the bad fuzz of vA poisoning/detox).
Since I am away without my vibration platform, I tried to improve my memory another way and we took Bacopa again. It works just after a couple of days, and makes life fun again! We take 1500 mg daily divided in two 750 mg doses. No side effects so far, apart from racing through the Sudoku and seing the funny side of situations.
Low lysine according to the PDE epilepsy treatment plan I looked at is 30-40mg per kg. I decided on max 3g a day. Luckily chronometer counts it. Meat is the highest. I’ve just reduced the amount of meat I eat. But not excluded meat as it’s nutritionally valuable. Back to the largely pescatarian diet I followed for 30 years!! Irony. I hate restrictive diets but while I’m working on the psychological-energy aspects of healing it would seem wise to not create excess B6 inactivating metabolites from lysine metabolism. I believe that balancing my nervous system will be the ultimate cure for my seizure risk (healthier mitochondria/better NAD availability/reduced pyroluria), however, I really want to stay away from a perfect storm situation so am watching lysine intake. The lysine/arginine ratio matters too.
As always your insights are interesting. Definitely a vA-glutamate link. I’ve had many theories but this latest one of Meri’s about B6 deficiency makes a lot of sense. Blocks the GAD enzyme. I’d previously thought that aldehyde accumulation due to slow ALDHs, that then depletes B1 and B6, was leading to glutamate increase. But this novel lysine pathway makes a lot of sense. It depends on ALDH7A1 to work or the B6 inactivating metabolites accumulate.
@jaj We went back on Bacopa because I suggested it to you, feeling the pain for you. And we are very happy we did, for the moment.
Glutamate increase is also linked to the stratospheric amounts which are added to everything you buy. Because it is added to everything more and more, even sugar!!! In the hope of developing addiction to brands. Good luck and best wishes
@puddleduck Bacopa increases acetylcholine? No need for eggs then!