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nerve pain
Quote from
lil chick on June 14, 2023, 9:55 am
I've decided to start a thread on nerve pain.
I have occasionally had trouble with nerves, including ulnar tunnel (at other times of my life) and now armpit nerve pain.
My armpit nerve pain is triggered by things like toweling that "wing" area of my back roughly, or rolling over in bed. It feels like burning that emanates toward the pectoral area.
I have occasionally had nerve pain in my feet, but nothing chronic yet.
Nerve pain has been related to diabetes, and Grant has done a very good job of related VA to diabetes, so I think that this thread could be useful.
I've decided to start a thread on nerve pain.
I have occasionally had trouble with nerves, including ulnar tunnel (at other times of my life) and now armpit nerve pain.
My armpit nerve pain is triggered by things like toweling that "wing" area of my back roughly, or rolling over in bed. It feels like burning that emanates toward the pectoral area.
I have occasionally had nerve pain in my feet, but nothing chronic yet.
Nerve pain has been related to diabetes, and Grant has done a very good job of related VA to diabetes, so I think that this thread could be useful.
puddleduck and Andrew B have reacted to this post.
Quote from
lil chick on June 14, 2023, 9:57 am
https://ggenereux.blog/discussion/topic/electrical-feeling/
I thought I would include a pointer to this short discussion 2 years ago.
https://ggenereux.blog/discussion/topic/electrical-feeling/
I thought I would include a pointer to this short discussion 2 years ago.
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Quote from
lil chick on June 14, 2023, 10:03 am
I've always thought that my ulnar issues were helped by the raw milk that I get. I suppose I could increase that as an experiment.
edited to add that I'm also going to ramp up a bit on my leafy greens, as Andrew has mentioned that my alcohol consumption might run down my folate. I suppose that I tend to let the cows eat the greens.
I've always thought that my ulnar issues were helped by the raw milk that I get. I suppose I could increase that as an experiment.
edited to add that I'm also going to ramp up a bit on my leafy greens, as Andrew has mentioned that my alcohol consumption might run down my folate. I suppose that I tend to let the cows eat the greens.
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Quote from
Jenny on June 28, 2023, 5:09 am
Hi @lil-chick I’m not really doing forums atm but was searching for something and came across your novel nerve pain symptom. I am interested in any novel symptoms especially nerve symptoms (which I presume seizure onset comes under).
I’m working on a new theory of B6 deficiency which is entirely based on Meri Arthur work. Genetic B6 epilepsy is caused by mutations in the ALDH7A1 gene. This leads to accumulation of lysine breakdown metabolites that inactivate B6. I’m looking into the possibility that the vA detox has caused this syndrome by inactivating this enzyme and depleting B6. This can go along with folate depletion too. Like all ALDH enzymes the co-factor is NAD, so it connects to the NAD work. Luckily because there is a genetic syndrome, there is treatment. B6, follinic acid, low lysine/high arginine diet. Meri has done a great post on FB on the many things that slow this gene. Interestingly, one of them is increased sulphite. B6 needed for sulphur processing. I’m seeing all sorts of vicious cycles from this enzyme slowing down. It makes a lot of sense to me. Work in progress.
B6 deficiency is associated with peripheral neuropathy and seizures.
Hi @lil-chick I’m not really doing forums atm but was searching for something and came across your novel nerve pain symptom. I am interested in any novel symptoms especially nerve symptoms (which I presume seizure onset comes under).
I’m working on a new theory of B6 deficiency which is entirely based on Meri Arthur work. Genetic B6 epilepsy is caused by mutations in the ALDH7A1 gene. This leads to accumulation of lysine breakdown metabolites that inactivate B6. I’m looking into the possibility that the vA detox has caused this syndrome by inactivating this enzyme and depleting B6. This can go along with folate depletion too. Like all ALDH enzymes the co-factor is NAD, so it connects to the NAD work. Luckily because there is a genetic syndrome, there is treatment. B6, follinic acid, low lysine/high arginine diet. Meri has done a great post on FB on the many things that slow this gene. Interestingly, one of them is increased sulphite. B6 needed for sulphur processing. I’m seeing all sorts of vicious cycles from this enzyme slowing down. It makes a lot of sense to me. Work in progress.
B6 deficiency is associated with peripheral neuropathy and seizures.
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puddleducklil chickAudreykathy55woodAndrew B
Quote from
lil chick on June 28, 2023, 5:13 am
I've suspected B6 helps because it would be present in my raw milk which seems to help... but (and I'm not sure how much less) it is less in pasteurized.
I've suspected B6 helps because it would be present in my raw milk which seems to help... but (and I'm not sure how much less) it is less in pasteurized.
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Quote from
Jenny on June 28, 2023, 6:00 am
Interesting. This is all a new concept to me - that I’ve got v. low B6 particularly in brain - so I’m currently thinking about it. Meri Arthur will be doing some more of her excellent videos at some point (YouTube ‘weak therefore strong’) and posts on FB. This idea is entirely based in her work and the private chats we’ve had.
There are a number of boxes that this theory ticks. A number of perplexing questions that I’ve never answered. When a theory ticks a lot of boxes then it needs taking seriously. The vA toxicity theory did. The choline deficiency theory did. The NAD deficiency theory did. Now this B6 deficiency theory has given me a number of light bulb moments. They are all theories of course, but ones that seem to hold weight, at least for me.
B6 is also depleted by pyroluria, which I tested positive for in 2015. However, I’ve addressed this. It did not seem possible that I was still B6 deficient. I knew aldehydes depleted B6 and have long thought my issue is slow ALDHs. However, I did not know that if ALDH7A1 was impacted the result was products from lysine metabolism such as P6C that inactivate B6. A triple whammy - depleting all the B6. This can cause low folate, and follinic acid is on the treatment plan for this genetic syndrome (B6 deficiency epilepsy). Low B6 and folate are the result of slow ALDH7A1 but they then become causes of this, through sulphur and methylation issues. Most chronic health issues involve ever worsening vicious cycles. I’m seeing a lot. Knowing how to break them at multiple points is the best way to health I think. If you don’t know what they are though, you can’t break them.
Interesting. This is all a new concept to me - that I’ve got v. low B6 particularly in brain - so I’m currently thinking about it. Meri Arthur will be doing some more of her excellent videos at some point (YouTube ‘weak therefore strong’) and posts on FB. This idea is entirely based in her work and the private chats we’ve had.
There are a number of boxes that this theory ticks. A number of perplexing questions that I’ve never answered. When a theory ticks a lot of boxes then it needs taking seriously. The vA toxicity theory did. The choline deficiency theory did. The NAD deficiency theory did. Now this B6 deficiency theory has given me a number of light bulb moments. They are all theories of course, but ones that seem to hold weight, at least for me.
B6 is also depleted by pyroluria, which I tested positive for in 2015. However, I’ve addressed this. It did not seem possible that I was still B6 deficient. I knew aldehydes depleted B6 and have long thought my issue is slow ALDHs. However, I did not know that if ALDH7A1 was impacted the result was products from lysine metabolism such as P6C that inactivate B6. A triple whammy - depleting all the B6. This can cause low folate, and follinic acid is on the treatment plan for this genetic syndrome (B6 deficiency epilepsy). Low B6 and folate are the result of slow ALDH7A1 but they then become causes of this, through sulphur and methylation issues. Most chronic health issues involve ever worsening vicious cycles. I’m seeing a lot. Knowing how to break them at multiple points is the best way to health I think. If you don’t know what they are though, you can’t break them.
puddleduck, lil chick and 3 other users have reacted to this post.
puddleducklil chickAudreyAndrew BInger
Quote from
lil chick on June 28, 2023, 6:58 am
Hi Jenny! Did. you see my post about idiopathic inter cranial hypertension? I know you aren't able to spend a lot of time on the inter webs.
I'll sum it up for you, I've cut back on tyramine sources. ie, trying to eat mostly very fresh foods. In my usual casual way, LOL, not going nuts just cutting back.
I had a bizarre reaction to antibiotics (triggered my migraines and other symptoms) and found a page which explained that vitamin A, antibiotics, steroids, tyramine can effect some people oddly because they don't detox them well and they end up acting as neurotransmitters.
It's a fairly popular thing migrainers try.
https://ggenereux.blog/discussion/topic/idiopathic-intracranial-hypertension/
Hi Jenny! Did. you see my post about idiopathic inter cranial hypertension? I know you aren't able to spend a lot of time on the inter webs.
I'll sum it up for you, I've cut back on tyramine sources. ie, trying to eat mostly very fresh foods. In my usual casual way, LOL, not going nuts just cutting back.
I had a bizarre reaction to antibiotics (triggered my migraines and other symptoms) and found a page which explained that vitamin A, antibiotics, steroids, tyramine can effect some people oddly because they don't detox them well and they end up acting as neurotransmitters.
It's a fairly popular thing migrainers try.
https://ggenereux.blog/discussion/topic/idiopathic-intracranial-hypertension/
Jenny and puddleduck have reacted to this post.
Quote from
Ourania on June 28, 2023, 7:33 am
I wonder what is the role of glutamate in all of this. Glutamate depletes b6 as it is needed for glutamate to GABA conversion, and just a small glutamate excess can have awful consequences.
I wonder if you have tried Brahmi (Bacopa monnieri), it is very useful for improving memory by removing extra glutamate from the brain and restoring the size of hippocampi.
I am sorry I cannot give links, I am on a telephone in the middle of nowhere, and for a few months too. Just wanted to float this to help if at all possible.
I wonder what is the role of glutamate in all of this. Glutamate depletes b6 as it is needed for glutamate to GABA conversion, and just a small glutamate excess can have awful consequences.
I wonder if you have tried Brahmi (Bacopa monnieri), it is very useful for improving memory by removing extra glutamate from the brain and restoring the size of hippocampi.
I am sorry I cannot give links, I am on a telephone in the middle of nowhere, and for a few months too. Just wanted to float this to help if at all possible.
Jenny, puddleduck and 3 other users have reacted to this post.
Jennypuddleducklil chickHermesAndrew B
Quote from
Jenny on July 3, 2023, 3:19 am
I think glutamate is highly significant and the big problem for me. I didn’t know that about Bacopa. I’m so wary of any supplements now as I’ve become so sensitive to everything. I’m probably avoiding things that could be helpful out of fear.
I think glutamate is highly significant and the big problem for me. I didn’t know that about Bacopa. I’m so wary of any supplements now as I’ve become so sensitive to everything. I’m probably avoiding things that could be helpful out of fear.
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puddleduckOuraniaHermesAndrew B
I posted this on another thread for Jenny, but meant to post it here, @ourania:
https://pubmed.ncbi.nlm.nih.gov/23875756/
Apparently blueberries may be helpful to the brain when excess glutamate is a problem.
I posted this on another thread for Jenny, but meant to post it here, @ourania:
https://pubmed.ncbi.nlm.nih.gov/23875756/
Apparently blueberries may be helpful to the brain when excess glutamate is a problem.
Jenny, Ourania and 2 other users have reacted to this post.
JennyOuraniaAndrew BDonald
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