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New interview with Dr. Garrett Smith
Quote from
Jiří on July 7, 2020, 7:30 am
Quote from
Matrixik on July 7, 2020, 6:54 am
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Jiří on July 7, 2020, 6:46 am
@orion What is the difference between allithiamine and benfotiamin?
Allithiamine/TTFD/Lipothiamine way easier cross into the brain without additional processing in the body.
https://www.hormonesmatter.com/navigating-thiamine-supplements/
Hm But I don't in your post anything about benfothiamin. They are both fat soluble. That's why I asked what is the difference. Here in CZ I can buy only benfothiamin version..
Quote from
Matrixik on July 7, 2020, 6:54 am
Quote from
Jiří on July 7, 2020, 6:46 am
@orion What is the difference between allithiamine and benfotiamin?
Allithiamine/TTFD/Lipothiamine way easier cross into the brain without additional processing in the body.
https://www.hormonesmatter.com/navigating-thiamine-supplements/
Hm But I don't in your post anything about benfothiamin. They are both fat soluble. That's why I asked what is the difference. Here in CZ I can buy only benfothiamin version..
Quote from
tim on July 7, 2020, 7:56 am
Has anyone read Lonsdale's book? If so, can you please advise why he thinks thiamine megadoses are necessary? The logical approach must be rather to work out what is causing the lack of absorption, increased excretion or lack of enzymatic transformation in thiamin deficiency but I'm interested to hear his argument.
Has anyone read Lonsdale's book? If so, can you please advise why he thinks thiamine megadoses are necessary? The logical approach must be rather to work out what is causing the lack of absorption, increased excretion or lack of enzymatic transformation in thiamin deficiency but I'm interested to hear his argument.
Quote from
Jiří on July 7, 2020, 8:10 am
Some video about B1. That guy is crazy into B1 research.
https://www.youtube.com/watch?v=nuIhjlFYYZY
Some video about B1. That guy is crazy into B1 research.
https://www.youtube.com/watch?v=nuIhjlFYYZY
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Orion on July 7, 2020, 8:11 am
@jiri Ah sorry meant to post this link:
https://www.hormonesmatter.com/ttfd-thiamine-derivative/
Without going into the biochemical details, what we now know is that thiamine tetrahydrofurfuryl disulfide (TTFD, Lipothiamine) is, for a number of reasons, the best of the bunch of synthetically produced derivatives and has exciting possibilities in therapy. For example, it has been shown from animal studies that Benfotiamine, a non-disulfide derivative, does not get into the brain whereas TTFD enables absorption of thiamine into the brain where it stimulates energy synthesis. When we take in thiamine, occurring only in our naturally formed food, it is biologically inert. It has to be “activated” within the body that possesses genetically determined mechanisms for its absorption and activation. To cut a technically difficult explanation, let me state that TTFD bypasses this process. It enables thiamine to split away from its disulfide attachment and enter the cells where its activity is required. The concentration achieved in the target cells is much greater than that achieved by the administration of the thiamine from which it was derived.
@jiri Ah sorry meant to post this link:
About TTFD: A Thiamine Derivative
Without going into the biochemical details, what we now know is that thiamine tetrahydrofurfuryl disulfide (TTFD, Lipothiamine) is, for a number of reasons, the best of the bunch of synthetically produced derivatives and has exciting possibilities in therapy. For example, it has been shown from animal studies that Benfotiamine, a non-disulfide derivative, does not get into the brain whereas TTFD enables absorption of thiamine into the brain where it stimulates energy synthesis. When we take in thiamine, occurring only in our naturally formed food, it is biologically inert. It has to be “activated” within the body that possesses genetically determined mechanisms for its absorption and activation. To cut a technically difficult explanation, let me state that TTFD bypasses this process. It enables thiamine to split away from its disulfide attachment and enter the cells where its activity is required. The concentration achieved in the target cells is much greater than that achieved by the administration of the thiamine from which it was derived.
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Orion on July 7, 2020, 8:16 am
@tim-2 Haven't read his books, but I think his approach is we don't activate B1 due to whatever reasons, don't think he is on the VA toxicity train. So taking the fat soluble active form, kickstarts the system, by getting active B1 into cells, and he believes that big doses help.
@tim-2 Haven't read his books, but I think his approach is we don't activate B1 due to whatever reasons, don't think he is on the VA toxicity train. So taking the fat soluble active form, kickstarts the system, by getting active B1 into cells, and he believes that big doses help.
tim and Ourania have reacted to this post.
Quote from
Jiří on July 7, 2020, 8:20 am
@orion hm I am not so sure about forms of vitamins that bypass some regulatory process in the body. Same as methycobalamin. Where I am not so sure if it is safe.. Anyway I do wonder if I am low in thiamin even when I take B complex and even here and there 100mg capsuls of thiamin.. Maybe I should try bigger doses like some people take 1000-1500mg and say it works.. For now I will try 100mg capsule 3 times a day and will see if I feel any different. Hopefully I will not deplete B2 with that or something..
@orion hm I am not so sure about forms of vitamins that bypass some regulatory process in the body. Same as methycobalamin. Where I am not so sure if it is safe.. Anyway I do wonder if I am low in thiamin even when I take B complex and even here and there 100mg capsuls of thiamin.. Maybe I should try bigger doses like some people take 1000-1500mg and say it works.. For now I will try 100mg capsule 3 times a day and will see if I feel any different. Hopefully I will not deplete B2 with that or something..
Quote from
Tropico on July 7, 2020, 8:21 am
Quote from
tim on July 7, 2020, 7:56 am
Has anyone read Lonsdale's book? If so, can you please advise why he thinks thiamine megadoses are necessary? The logical approach must be rather to work out what is causing the lack of absorption, increased excretion or lack of enzymatic transformation in thiamin deficiency but I'm interested to hear his argument.
Megadoses are necessary to switch from a catabolic to anabolic metabolism. Chronic disease and/or wrong diets and/or stress downregulates metabolism.
Quote from
tim on July 7, 2020, 7:56 am
Has anyone read Lonsdale's book? If so, can you please advise why he thinks thiamine megadoses are necessary? The logical approach must be rather to work out what is causing the lack of absorption, increased excretion or lack of enzymatic transformation in thiamin deficiency but I'm interested to hear his argument.
Megadoses are necessary to switch from a catabolic to anabolic metabolism. Chronic disease and/or wrong diets and/or stress downregulates metabolism.
Quote from
Ourania on July 7, 2020, 8:24 am
Yes, he thinks TTFD is best. It also has much more research into it.
As far as I know, there are two TTFD products I know of: Allithiamine (which is a brand name, not allithiamine which is the natural substance) and Lipothiamine which is endorsed by Dr Lonsdale.
In Allithiamine there is also some phosphorus. In Lipothiamine there is a little ALA which was very problematic for me most probably because of mercury amalgam problems.
I have two observations to make:
Lipothiamine is not problematic anymore after 7 months of VA avoidance.
Both TTFD products gave me what I now recognize as VA detox symptoms. Benfotiamine did not. Maybe Benfotiamine does not help with VA excretion?
Yes, he thinks TTFD is best. It also has much more research into it.
As far as I know, there are two TTFD products I know of: Allithiamine (which is a brand name, not allithiamine which is the natural substance) and Lipothiamine which is endorsed by Dr Lonsdale.
In Allithiamine there is also some phosphorus. In Lipothiamine there is a little ALA which was very problematic for me most probably because of mercury amalgam problems.
I have two observations to make:
Lipothiamine is not problematic anymore after 7 months of VA avoidance.
Both TTFD products gave me what I now recognize as VA detox symptoms. Benfotiamine did not. Maybe Benfotiamine does not help with VA excretion?
Quote from
Orion on July 7, 2020, 8:24 am
@jiri I tried 1600mg B1 HCl per day for couple months after studies showed that amount could help after accutane, but tried that before low VA and it didn't help. Let me know how you feel on it, it is supposed to kickstart the B1 system via saturation.
Lonsdale mentions that high amounts of B1 won't dis-regulate the other Bs, hopefully he is correct on this point.
@jiri I tried 1600mg B1 HCl per day for couple months after studies showed that amount could help after accutane, but tried that before low VA and it didn't help. Let me know how you feel on it, it is supposed to kickstart the B1 system via saturation.
Lonsdale mentions that high amounts of B1 won't dis-regulate the other Bs, hopefully he is correct on this point.
Quote from
tim on July 7, 2020, 8:45 am
Riboflavin deficiency affects from about 60% to 95% of the population depending on the demographic... vA excess has to be a big player in these B deficiency epidemics.
Riboflavin deficiency affects from about 60% to 95% of the population depending on the demographic... vA excess has to be a big player in these B deficiency epidemics.
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