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Vitamin K deficiency
Quote from Tommy on October 29, 2023, 3:01 amI’ve been eating pretty much anything that is low in vitamin A.
Potatoes, Rice, beans, beef and chicken are my staples.
But I also will eat bread and other cooked grains, lean fish, low A fruits, olive oil, nuts, low A vegetables as part of recipes that I cook.
I have recently introduced natto into my diet, hoping that it can help improve my vitamin k status.
do you take a lot of salt? Do you eat brown or white rice?
Quote from Tommy on October 29, 2023, 3:01 amI’ve been eating pretty much anything that is low in vitamin A.
Potatoes, Rice, beans, beef and chicken are my staples.
But I also will eat bread and other cooked grains, lean fish, low A fruits, olive oil, nuts, low A vegetables as part of recipes that I cook.
I have recently introduced natto into my diet, hoping that it can help improve my vitamin k status.
Se ha encontrado que grandes dosis de vitamina A y vitamina E antagonizan a la vitamina K (8). El exceso de vitamina A parece interferir con la absorción de vitamina K, mientras que la vitamina E podría inhibir la actividad de enzimas carboxilasas dependientes de vitamina K e interferir con la cascada de coagulación . Un estudio en adultos con estados de coagulación normales encontró que la suplementación con 1,000 UI de vitamina E por 12 semanas disminuyó la γ-carboxilación de protrombina, una proteína dependiente de vitamina K . Individuos que toman drogas anticoagulantes como la warfarina y aquellos que son deficientes de vitamina K no deberían tomar suplementos de vitamina E sin una supervisión médica minuciosa debido al riesgo incrementado de hemorragia (sangrado excesivo
Quote from Tommy on October 29, 2023, 3:01 amI’ve been eating pretty much anything that is low in vitamin A.
Potatoes, Rice, beans, beef and chicken are my staples.
But I also will eat bread and other cooked grains, lean fish, low A fruits, olive oil, nuts, low A vegetables as part of recipes that I cook.
I have recently introduced natto into my diet, hoping that it can help improve my vitamin k status.
An adequate nutritional status of copper is necessary for normal iron metabolism and the formation of red blood cells. Anemia is a clinical sign of copper deficiency, and iron has been found accumulated in the livers of copper-deficient animals, indicating that copper (via ceruloplasmin) is required for iron transport to the bloodstream. bone marrow for the formation of red blood cells (see Iron metabolism) (2). The connection between copper availability and iron metabolism has also been established in humans; a copper deficiency can lead to a secondary ceruloplasmin deficiency and hepatic iron overload and/or cirrhosis (10). Oral copper supplementation restored normal levels of ceruloplasmin and plasma ferroxidase activity and corrected the disorder of iron metabolism in a subject with copper deficiency (14). Furthermore, infants fed high-iron formulas absorbed less copper than infants fed low-iron formulas, suggesting that high iron intakes in infants may interfere with copper absorption. Maybe you have copper deficiency. zinc supplements do the same
Quote from Tommy on October 29, 2023, 2:10 amJust providing an update on my vitamin k situation…
It seems that I am now getting bleeding gums. I suspect that this may be a manifestation of my extreme vitamin k deficiency. Vitamin C seems to help greatly with this but still isn’t able to completely alleviate the issue.
This got me thinking…
Perhaps the reason why carnivores don’t seem to run into issues with vitamin C deficiency, (other than the absence of sugar in their diet) is because their diet is rich in highly bioavailable and absorbable vitamin K2.
Interestingly enough, Grant has a diet that has virtually no vitamin C but is rich in vitamin k (K2 from fatty beef or bison).
This would imply some sort of interaction/relationship between vitamin K and C, but once again this is a half baked post that isn’t really backed by any research from my end.
Would love to know anyones thoughts or ideas.
High supplemental zinc intakes of 50 mg/day or more for extended periods of time can result in copper deficiency. A high dietary intake of zinc increases the synthesis of a cellular protein called metallothionein, which binds to certain metals and prevents their absorption by trapping them in intestinal cells. Metallothionein has a higher affinity for copper than zinc, which is why high levels of metallothionein induced by excess zinc cause a decrease in copper absorption. In contrast, high intakes of copper have not been found to affect zinc nutritional status (2, 15). Zinc supplementation (10 mg/day for 8 weeks) was able to restore normal plasma copper/zinc ratios in 65 long-term hemodialysis subjects who initially exhibited low zinc levels and elevated copper levels. Whether improving zinc and copper status in hemodialysis patients can impact their clinical outcomes still needs to be evaluated (16).
Fructose
High-fructose diets have exacerbated copper deficiency in rats but not in pigs, which have a gastrointestinal system more similar to that of humans. Very high levels of dietary fructose (20% of total calories) did not result in a reduction of copper in humans, suggesting that fructose intake does not result in a reduction of copper at relevant levels of normal diets (2, 15).
Vitamin C
Although vitamin C supplements have produced copper deficiency in guinea pigs (17), the effect of vitamin C supplements on copper nutritional status in humans is less clear. Two minor studies in healthy young adult men indicate that ceruloplasmin oxidase activity may be impaired by relatively high doses of supplemental vitamin C. In one study, vitamin C supplementation at 1,500 mg/day for two months resulted in a significant decrease in ceruloplasmin oxidase activity (18). In the other study, supplementation of 605 mg of vitamin C/day for three weeks caused a decrease in ceruloplasmin oxidase activity, although copper absorption did not decrease (19). None of these studies found that vitamin C supplementation adversely affected copper nutritional status.
You might ask me what this has to do with it. because carnivores do not have the detoxification twist. Why don't they take zinc supplements? According to Grant's survey, 80% take a zinc supplement. They don't eat fructose a lot of people eat fruit. and they don't take vitamin c. Many of you take a vitamin C supplement. All of this causes serious water and iron poisoning at the liver level because you all eat a diet very low in copper. and you take things that lower copper more. Grant didn't do that. Their diet is moderate to high in copper. brown rice has a lot of copper.
As I mentioned earlier, low copper intake leads to low iron anemia. Interestingly, a low level of iron is accompanied by a deficiency of vitamin A. This indicates that iron and vitamins are accumulating at the level of the liver. Increases copper and iron and vitamin A are released from the liver surprise. There we have the so-called detoxification regression.
Vitamin A deficiency frequently coexists with iron deficiency and can exacerbate iron deficiency anemia by altering iron metabolism (27). Vitamin A supplementation has beneficial effects on iron deficiency anemia and improves iron nutritional status among children and pregnant women (27, 28). Combining vitamin A and iron supplements appears to reduce anemia more effectively than iron or vitamin A supplementation alone (31). Additionally, studies in rats have shown that iron deficiency alters vitamin A levels in plasma and liver.
summary without copper, iron accumulates in the liver. Without iron in the body, vitamin A accumulates even more in the liver. and the consumption of zinc, vitamin C and fructose supplements that lower copper is being promoted. and that causes iron accumulation and leads to vitamin accumulation even more at the liver level. The one that releases does not have the protection of iron so that it is not as toxic or copper. This is how the detoxification setback occurs.
On the other hand, if you have a diet very low in copper, even if it is high in zinc, iron accumulates in the liver. Zinc is important at the liver level for detoxification of vitamin A. Both compete with the same road. high iron in the liver, low zinc at the liver level. Zinc supplement makes everything even worse
Iron and zinc compete for absorption pathways (18). Supplemental (38-65 mg/day elemental iron) but not dietary iron levels may decrease zinc absorption (18, 19). This interaction is of concern in the management of iron supplementation during pregnancy and lactation and has led some experts to recommend zinc supplementation for pregnant and lactating women taking iron supplements (20, 21). Fortification of foods with iron has not been shown to negatively affect zinc absorption (22). In a placebo-controlled study, zinc supplementation (10 mg/day) for three months in children aged eight to nine years significantly decreased serum iron concentrations, but not to the point of causing anemia (23). Additional randomized controlled studies reported worsening iron nutritional status with chronic zinc supplementation (24, 25).
Calcium
High levels of dietary calcium impair zinc absorption in animals, but it is unclear whether this occurs in humans (17). One study showed that increasing the calcium intake of postmenopausal women by 890 mg/day in the form of milk or calcium phosphate (total calcium intake, 1,360 mg/day) reduced zinc absorption and zinc balance in postmenopausal women (26). However, another study found that increasing adolescent girls' calcium intake by 1,000 mg/day in the form of calcium citrate malate (total calcium intake, 1,667 mg/day) did not affect zinc absorption or balance (27 ). Calcium in combination with phytate could affect zinc absorption, which would be particularly relevant for people who frequently consume tortillas made with lime (i.e., calcium oxide). A study in 10 healthy women (age range, 21-47 years) found that high dietary calcium intake (~1,800 mg/day) did not impair zinc absorption regardless of dietary phytate content (28). For more information on phytate, see Food Sources.
Many here improve the regression ogengef intoxication with chocolate. Chocolate is rich in copper. Grant Genereux drank black coffee. coffee is very high in copper. I hope these posts all reach a lot of people.
El zinc y la vitamina A interactúan de varias maneras. El zinc es un componente de la proteína fijadora de retinol, una proteína necesaria para transportar la vitamina A en la sangre. El zinc también es necesario para la enzima que convierte el retinol (vitamina A) en retina. Esta última forma de vitamina A es necesaria para la síntesis de rodopsina, una proteína del ojo que absorbe la luz y, por tanto, participa en la adaptación a la oscuridad. La deficiencia de zinc se ha asociado con una menor liberación de vitamina A desde el hígado, lo que puede contribuir a los síntomas de ceguera nocturna que se observan con la deficiencia de zinc (31, 32) .