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Your brain needs glucose

#11 · June 10, 2024, 9:46 am

Quote from Janelle525 on June 10, 2024, 9:46 am
He mentions these on his website:

CONDITIONS THAT RESPOND WELL TO BRAIN REHABILITATION:

Physical Conditions:

Chronic Headaches or Migraines

Tinnitus or Ear-Ringing

Low Energy

Dizziness

Brain Fog

Autism

Auto-immune Disorders

Light and Sound Sensitivity

Neuropathy

Mental Conditions

Anxiety

Depression

Chronic Feelings of Worthlessness or Failure

Anger

Irritability

Hopelessness

Suicidal Thoughts or Behaviors

Panic

Paranoia

Hallucinations

Mania

Cognitive Conditions:

Attention Problems

Difficulty finding Words You Want to Use

Memory Problems

Difficulty filtering out conversations and other Noises

Learning Disabilities

Behavioral Problems:

Addiction (substance abuse, pornography, etc.)

Violence (Domestic Violence, Property Damage, Fighting)

Hyperactivity

Acting out at School

Disobedience to Parents

Rule or Law Breaking

Laziness

Low Motivation

Difficulties Maintaining Relationships or Jobs

"The work Dr. Stephens has done with hundreds of people indicates that the primary problem in human functioning (brain regulation, body regulation, emotional regulation, cognitive regulation, behavioral regulation, neurochemical regulation, and spiritual regulation) is a lack of fuel to the brain due to injuries and traumas ranging from very minor and unrecognized ones to major ones that have devastated the person’s life. Glucose is the fuel for the brain. When the brain does not receive sufficient fuel (or glucose) as you can read about on the other papers on this website, none of those regulatory mechanisms mentioned above function as they should. The result is a variety of physical problems and illnesses such as headaches, ear-ringing, light and sound sensitivity, autoimmune disorders such as rheumatoid arthritis and others, endocrine disorders such as diabetes and others, etc.; cognitive problems such as memory and attention difficulties; developmental problems such as autism; emotional regulation problems such as anger, anxiety, and depression; and behavioral control problems such as addictions, criminal behavior, relational aggression and violence, and a number of other difficulties."

Eczema would fall under autoimmune conditions. We don't quite know why he developed kidney failure. But either way the beef rice and beans cured it.

He does coach people on relearning new behaviors and new ways of thinking about themselves when they have given the brain enough fuel, but this is more than just calming down our nervous system. The nervous system can't calm down if it doesn't have the fuel. Which is why so many see their anxiety go away in ketosis, they are finally getting at least some fuel to their brain! Many people have healed using refeeding approaches as well so no I don't think I agree with him that only dextrose can heal the brain. I think as long as we give enough glucose through starches and sugars then it can heal. He had to come up with a protocol for sick people though, what sick person wants to change their diet? Changing your diet when you feel hopeless takes a ton of willpower (and lots of glucose to your brain to make those changes!) Adding glucose to your regular diet seems simple and cheap and makes treating a patient easier because you can see how much they are using.

He mentions that someone with type 1 diabetes was able to go off insulin with his protocol. This was thought of as a complete loss of insulin in the pancreas never to be cured, so how is that possible?!

He mentions these on his website:

CONDITIONS THAT RESPOND WELL TO BRAIN REHABILITATION:

Physical Conditions:

Chronic Headaches or Migraines

Tinnitus or Ear-Ringing

Low Energy

Dizziness

Brain Fog

Autism

Auto-immune Disorders

Light and Sound Sensitivity

Neuropathy

Mental Conditions

Anxiety

Depression

Chronic Feelings of Worthlessness or Failure

Anger

Irritability

Hopelessness

Suicidal Thoughts or Behaviors

Panic

Paranoia

Hallucinations

Mania

Cognitive Conditions:

Attention Problems

Difficulty finding Words You Want to Use

Memory Problems

Difficulty filtering out conversations and other Noises

Learning Disabilities

Behavioral Problems:

Addiction (substance abuse, pornography, etc.)

Violence (Domestic Violence, Property Damage, Fighting)

Hyperactivity

Acting out at School

Disobedience to Parents

Rule or Law Breaking

Laziness

Low Motivation

Difficulties Maintaining Relationships or Jobs

"The work Dr. Stephens has done with hundreds of people indicates that the primary problem in human functioning (brain regulation, body regulation, emotional regulation, cognitive regulation, behavioral regulation, neurochemical regulation, and spiritual regulation) is a lack of fuel to the brain due to injuries and traumas ranging from very minor and unrecognized ones to major ones that have devastated the person’s life. Glucose is the fuel for the brain. When the brain does not receive sufficient fuel (or glucose) as you can read about on the other papers on this website, none of those regulatory mechanisms mentioned above function as they should. The result is a variety of physical problems and illnesses such as headaches, ear-ringing, light and sound sensitivity, autoimmune disorders such as rheumatoid arthritis and others, endocrine disorders such as diabetes and others, etc.; cognitive problems such as memory and attention difficulties; developmental problems such as autism; emotional regulation problems such as anger, anxiety, and depression; and behavioral control problems such as addictions, criminal behavior, relational aggression and violence, and a number of other difficulties."

Eczema would fall under autoimmune conditions. We don't quite know why he developed kidney failure. But either way the beef rice and beans cured it.

He does coach people on relearning new behaviors and new ways of thinking about themselves when they have given the brain enough fuel, but this is more than just calming down our nervous system. The nervous system can't calm down if it doesn't have the fuel. Which is why so many see their anxiety go away in ketosis, they are finally getting at least some fuel to their brain! Many people have healed using refeeding approaches as well so no I don't think I agree with him that only dextrose can heal the brain. I think as long as we give enough glucose through starches and sugars then it can heal. He had to come up with a protocol for sick people though, what sick person wants to change their diet? Changing your diet when you feel hopeless takes a ton of willpower (and lots of glucose to your brain to make those changes!) Adding glucose to your regular diet seems simple and cheap and makes treating a patient easier because you can see how much they are using.

He mentions that someone with type 1 diabetes was able to go off insulin with his protocol. This was thought of as a complete loss of insulin in the pancreas never to be cured, so how is that possible?!

#12 · June 10, 2024, 12:19 pm

I googled dextrose and ordered 2kg of the stuff.
It was sold in a muscle building store as a supplement for workouts.
So the gymrats were running around with the best brains inadvertently??

The more I think about it the more I dont buy the theory. Arent we getting tons and tons of glucose in our diets.

Plus the guy has many red flags of a charlatan

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#13 · June 10, 2024, 2:07 pm

Quote from Diogenes on June 10, 2024, 12:19 pm

I googled dextrose and ordered 2kg of the stuff.
It was sold in a muscle building store as a supplement for workouts.
So the gymrats were running around with the best brains inadvertently??

The more I think about it the more I dont buy the theory. Arent we getting tons and tons of glucose in our diets.

Plus the guy has many red flags of a charlatan

It's completely individual even different in the same family and varies by the day. If you went and bought the dextrose sounds like you have some problems on the list that you'd like to heal?

I don't have mood problems when I'm getting enough glucose. But I do have a buttcrack rash that may need over and beyond what I usually get in my diet as my metabolism can be pretty high the other day my temp hit 99.1

His basic protocol has you start with 24 grams of dextrose 4 times a day, and then increase until symptoms are gone, that's on top of any you are getting in your diet. That's a significant amounts of carbs. Very hard to hit that number without adding something on top of your diet or just shoveling in the rice and pasta.

What makes him seem like a charlatan? His religious views? He didn't mention anything weird in the interview, he seemed completely normal to me. Spoke very well without signs of lying.

#14 · June 10, 2024, 2:50 pm

I've decided I'm going to try the protocol. I have a history of chronic undereating, underweight, panic disorder, feelings of worthlessness, hypomania, difficulty finding words, sudden feelings of sleepiness, light and sound sensitivity, and a buttcrack rash with itchy peely skin that has never gone away for 8 yrs (wow). Most of these have cleared up with regular starch eating. The only thing left is sometimes sleepiness and memory issues (usually after not getting enough salt and carbs), light sensitivity, rash, at times wanting to undereat and I also have trouble staying asleep most nights I wake up a lot.

24 grams 4 times a day so at each meal and once before bed for 6 months, increasing the whole time until symptoms completely heal.

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#15 · June 10, 2024, 3:56 pm

Quote from Jessica2 on June 10, 2024, 3:37 pm

One thing I noticed he said in the podcast was he had a 100% sucess rate...with those who finished his protocol. So maybe for some it isn't successful and they quit early. He didn't give a specific reason why they quit really, he surmised maybe some felt better sooner but that wasn't definitive.

I am skeptical (no surprise there since we know I don't like carbs and grains haha) but very interested in hearing results from those who are willing to experiment.

He has the data on his website:

An overview of this data is as follows (all data is as of July, 2020):

247 people completed Reclamation and Recovery (it was called glucose treatment at the time)
Of these 247, all 247 had achieved complete recovery as indicated by the following:
1. Pre-post neuropsychological assessment indicated full cognitive function and recovery
2. Elimination of all symptoms that brought them to Dr. Stephens
3. Elimination of symptoms beyond what brought them to Dr. Stephens
326 people were actively engaged in Reclamation and Recovery (called glucose treatment at the time) and were experiencing reduction of symptoms and progressive recovery
95% of people who completed at least 5 sessions finished treatment and all of those who finished treatment experienced recovery as defined above
As of July, 2020, approximately 300 people had either scheduled an initial appointment that they never kept, or attended 1 or 2 sessions and discontinued treatment for a variety of reasons (moved, found a different provider, and most commonly had concerns about the glucose element of the treatment)

https://www.peakneuropsych.com/reclamation-and-recovery

He's a psychologist so he has to maintain patient confidentiality.

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#16 · June 11, 2024, 1:34 am

Quote from Janelle525 on June 10, 2024, 2:50 pm

24 grams 4 times a day so at each meal and once before bed for 6 months, increasing the whole time until symptoms completely heal.

The dextrose I ordered, the instruction said to take 80g with 200ml of water.

So have gym bros figured it out and we should all just look up to them. Theyre brains most be running like clockwork

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#17 · June 11, 2024, 4:54 am

Thank you for sharing, very interesting theory and topic!

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#18 · June 11, 2024, 8:15 am

Quote from Janelle525 on June 11, 2024, 8:15 am

Quote from Jessica2 on June 10, 2024, 4:17 pm

Well I am looking forward to see if it helps you! There's nothing like experience to trump statistics. I do notice that none of his success has anything to do with weight and he doesn't claim to help with weight issues. You wouldn't expect so as a psychologist, but I do wonder still about excess glucose and liponeogenesis which, unless you don't want to believe all the scientific literature on it says, happens with excess glucose. Not sure I would attempt the experiment if I had blood sugar or weight issues, and again what he said about keto and blood sugar doesn't really make sense to me at least. Somehow you get more glucose than you would actually eating things with glucose? I just don't know if I buy that but who knows? Looking forward to hear what others say about taking it.

Yeah I mean if someone is already 100 lbs overweight then they should be on carnivore already trying to lose it, then they could add the glucose on top of the carnivore diet if they are having any of the symptoms on the list. Obviously that would kick them out of ketosis but if it isn't clearing up their brain problems then I think it's worth a shot to try the glucose.

For those who are concerned about fat gain consuming all that glucose I think this is more of a concern for completely sedentary people. "Glycogen storage capacity in man is approximately 15 g/kg body weight and can accommodate a gain of approximately 500 g before net lipid synthesis contributes to increasing body fat mass. "

Fructose is more of a concern: "There is evidence from both human and animal studies that fructose is a more potent inducer of hepatic lipogenesis than glucose. This is most likely due to the liver’s prominent physiological role in fructose metabolism, which may be disrupted under pathological conditions by increased hepatic expression of fructolytic and lipogenic enzymes. "

"In contrast, glucose is taken up and metabolized by most mammalian tissues. The majority of glucose is taken up by the liver and muscle and stored as glycogen "

"Fructose consumption is thought to raise cortisol levels by promoting inflammatory processes in adipose tissue and stimulating the hypothalamus, resulting in the release of corticotropin-releasing factor. Cortisol increases the flux of FA from subcutaneous adipose tissue to visceral fat depots, impairing organ function (DiNicolantonio et al. 2018) and leading to an unfavorable fat distribution in lean individuals, i.e. a body shape described as thin outside, fat inside, which is associated with an increased risk for the metabolic syndrome (DiNicolantonio et al. 2018)" https://joe.bioscientifica.com/view/journals/joe/257/2/JOE-22-0270.xml

"Healthy subjects (n = 6) were challenged with sweetened beverages (85 g sugar) containing pure glucose (100:0) or mixtures of fructose and glucose (50:50 or 75:25) on three separate occasions in a random and blinded order. The beverages containing fructose stimulated DNL more potently compared with the beverages containing pure glucose." https://www.sciencedirect.com/science/article/pii/S0022316622098169?via%3Dihub

Yet another showing it is fructose that causes harm:

"Regular consumption of both fructose- and sucrose-sweetened beverages in moderate doses – associated with stable caloric intake – increases hepatic FA synthesis even in a basal state; this effect is not observed after glucose consumption." https://www.journal-of-hepatology.eu/article/S0168-8278(21)00161-6/fulltext

And another showing even despite weight gain with glucose it did not cause harm, it was fructose that did all the harm:

"Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle–triglyceride and –cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults." https://www.jci.org/articles/view/37385

Wow I was so duped by Ray Peat.... worst health of my entire life consuming excess sugar.

Quote from Jessica2 on June 10, 2024, 4:17 pm

Well I am looking forward to see if it helps you! There's nothing like experience to trump statistics. I do notice that none of his success has anything to do with weight and he doesn't claim to help with weight issues. You wouldn't expect so as a psychologist, but I do wonder still about excess glucose and liponeogenesis which, unless you don't want to believe all the scientific literature on it says, happens with excess glucose. Not sure I would attempt the experiment if I had blood sugar or weight issues, and again what he said about keto and blood sugar doesn't really make sense to me at least. Somehow you get more glucose than you would actually eating things with glucose? I just don't know if I buy that but who knows? Looking forward to hear what others say about taking it.

Yeah I mean if someone is already 100 lbs overweight then they should be on carnivore already trying to lose it, then they could add the glucose on top of the carnivore diet if they are having any of the symptoms on the list. Obviously that would kick them out of ketosis but if it isn't clearing up their brain problems then I think it's worth a shot to try the glucose.

For those who are concerned about fat gain consuming all that glucose I think this is more of a concern for completely sedentary people. "Glycogen storage capacity in man is approximately 15 g/kg body weight and can accommodate a gain of approximately 500 g before net lipid synthesis contributes to increasing body fat mass. "

Fructose is more of a concern: "There is evidence from both human and animal studies that fructose is a more potent inducer of hepatic lipogenesis than glucose. This is most likely due to the liver’s prominent physiological role in fructose metabolism, which may be disrupted under pathological conditions by increased hepatic expression of fructolytic and lipogenic enzymes. "

"In contrast, glucose is taken up and metabolized by most mammalian tissues. The majority of glucose is taken up by the liver and muscle and stored as glycogen "

"Fructose consumption is thought to raise cortisol levels by promoting inflammatory processes in adipose tissue and stimulating the hypothalamus, resulting in the release of corticotropin-releasing factor. Cortisol increases the flux of FA from subcutaneous adipose tissue to visceral fat depots, impairing organ function (DiNicolantonio et al. 2018) and leading to an unfavorable fat distribution in lean individuals, i.e. a body shape described as thin outside, fat inside, which is associated with an increased risk for the metabolic syndrome (DiNicolantonio et al. 2018)" https://joe.bioscientifica.com/view/journals/joe/257/2/JOE-22-0270.xml

"Healthy subjects (n = 6) were challenged with sweetened beverages (85 g sugar) containing pure glucose (100:0) or mixtures of fructose and glucose (50:50 or 75:25) on three separate occasions in a random and blinded order. The beverages containing fructose stimulated DNL more potently compared with the beverages containing pure glucose." https://www.sciencedirect.com/science/article/pii/S0022316622098169?via%3Dihub

Yet another showing it is fructose that causes harm:

"Regular consumption of both fructose- and sucrose-sweetened beverages in moderate doses – associated with stable caloric intake – increases hepatic FA synthesis even in a basal state; this effect is not observed after glucose consumption." https://www.journal-of-hepatology.eu/article/S0168-8278(21)00161-6/fulltext

And another showing even despite weight gain with glucose it did not cause harm, it was fructose that did all the harm:

"Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle–triglyceride and –cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults." https://www.jci.org/articles/view/37385

Wow I was so duped by Ray Peat.... worst health of my entire life consuming excess sugar.

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#19 · June 12, 2024, 6:40 am

Yeah I'm also wary about the dextrose claim too. Refined sugar consumption makes your mineral levels and ratios on a hair test worse and slowly burns you out, sure dextrose might be a much more efficient fuel but I would expect it to have a similar effect to sugar on ones mineral levels and ratios in the long run.

How much dextrose is that doctor recommending people take a day?

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#20 · June 12, 2024, 8:00 am

Quote from Janelle525 on June 12, 2024, 8:00 am
I'm honestly pretty skeptical too despite my posts here. It may only be helpful for those who are very clearly undereating fuel sources such as starch, kinda like anorexia but without the focus on trying to lose weight. Adrenaline causes someone to just not eat well. I've been through that so many times. I am eating well now though so I may not experience the benefits he claims. I've never really gone through a period of overfeeding though. I would do it for a time then stop, it would cause symptoms if I went too hard on calories. Typical of anorexia recovery but I'm not anorexic. Maybe orthorexic. Whenever I ease up on my usual diet that I think is healthy my brain says to stop by causing all kinds of random symptoms that make me think there's something wrong. I know it's happening, but I usually don't push through. I think this is very common with people with trauma. They just never get to full recovery. Gaining weight is a major reason to not push through as well. I'm not super subscribed to the idea we have to push through 100 lbs of weight gain, but if you do restrict restrict restrict sometimes the only thing that heals the brain is to not care how much weight you gain. Unfortunately. I was thinking maybe dextrose could replace all the potato chips and ice cream, but consuming enough fats is a part of recovery as well. I wish the brain wasn't so complicated! But alas we do have a very large brain and life isn't always about whether you consumed enough zinc or fill in the blank of whatever other nutrient we obsess about.

I mean do we really want to get to the end of life and God asks us what we did with the time and blessings he gave us and we say well I got enough folate everyday finally at the age of 40? I think a lot of us are orthorexic unfortunately.

To address the idea that glucose can burn us out just like sugar... I'm just not so sure. I have experienced near total bedbound burnout and never experienced that from eating refined starch. Maybe dextrose reacts different I will find out! Carbs do tend to make us anabolic, which is the state we heal in. If you are stuck in catabolism you just slowly die because you are not healing tissues the brain being a majorly important tissue. More and more issues will pop up as you age. And then dementia or something else will send you to eternity. We all die of something but damn I don't want to live in a state of being demented for 10 yrs of my life. Also, healing isn't always fun, it can cause symptoms. We don't like to feel any bad symptom so then we say it didn't work it made me feel worse!! well... have you ever healed from injury? was it painful? I bet you it was. I got bit in the face by a dog, the swelling was insane. Healing causes swelling. Most people freak out when their body swells though. That happens to people who restrict then start eating normally again, they swell up. They might freak out and say what the hell I gained 10 lbs overnight! This isn't working! yeah it is. Swelling heals. Happens to every single anorexic. They balloon up rapidly when they start eating lots of calories particularly carbs and fats. If they freak out, they will just go back to restriction and die an early death at the age of 45. I think those who feel okay on ketosis are just giving their brains at least some fuel whereas trying to get by on whatever glucose makes it to the brain after repeated trauma could cause all manner of disease. Overfeeding seems to be the only other answer besides ketosis.

I'm honestly pretty skeptical too despite my posts here. It may only be helpful for those who are very clearly undereating fuel sources such as starch, kinda like anorexia but without the focus on trying to lose weight. Adrenaline causes someone to just not eat well. I've been through that so many times. I am eating well now though so I may not experience the benefits he claims. I've never really gone through a period of overfeeding though. I would do it for a time then stop, it would cause symptoms if I went too hard on calories. Typical of anorexia recovery but I'm not anorexic. Maybe orthorexic. Whenever I ease up on my usual diet that I think is healthy my brain says to stop by causing all kinds of random symptoms that make me think there's something wrong. I know it's happening, but I usually don't push through. I think this is very common with people with trauma. They just never get to full recovery. Gaining weight is a major reason to not push through as well. I'm not super subscribed to the idea we have to push through 100 lbs of weight gain, but if you do restrict restrict restrict sometimes the only thing that heals the brain is to not care how much weight you gain. Unfortunately. I was thinking maybe dextrose could replace all the potato chips and ice cream, but consuming enough fats is a part of recovery as well. I wish the brain wasn't so complicated! But alas we do have a very large brain and life isn't always about whether you consumed enough zinc or fill in the blank of whatever other nutrient we obsess about.

I mean do we really want to get to the end of life and God asks us what we did with the time and blessings he gave us and we say well I got enough folate everyday finally at the age of 40? I think a lot of us are orthorexic unfortunately.

To address the idea that glucose can burn us out just like sugar... I'm just not so sure. I have experienced near total bedbound burnout and never experienced that from eating refined starch. Maybe dextrose reacts different I will find out! Carbs do tend to make us anabolic, which is the state we heal in. If you are stuck in catabolism you just slowly die because you are not healing tissues the brain being a majorly important tissue. More and more issues will pop up as you age. And then dementia or something else will send you to eternity. We all die of something but damn I don't want to live in a state of being demented for 10 yrs of my life. Also, healing isn't always fun, it can cause symptoms. We don't like to feel any bad symptom so then we say it didn't work it made me feel worse!! well... have you ever healed from injury? was it painful? I bet you it was. I got bit in the face by a dog, the swelling was insane. Healing causes swelling. Most people freak out when their body swells though. That happens to people who restrict then start eating normally again, they swell up. They might freak out and say what the hell I gained 10 lbs overnight! This isn't working! yeah it is. Swelling heals. Happens to every single anorexic. They balloon up rapidly when they start eating lots of calories particularly carbs and fats. If they freak out, they will just go back to restriction and die an early death at the age of 45. I think those who feel okay on ketosis are just giving their brains at least some fuel whereas trying to get by on whatever glucose makes it to the brain after repeated trauma could cause all manner of disease. Overfeeding seems to be the only other answer besides ketosis.

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Your brain needs glucose