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A theory on enhancing Vitamin A excretion by enhancing glucuronidation
Quote from
tim on October 31, 2021, 6:00 am
@jeremy
B12 deficiency is not normally caused by a lack of B12 in the diet. B12 absorption is complex and can easily be compromised. Supplements contain mega doses and some of it gets absorbed without instrinsic factor. As discussed above, proper enzyme function is required to properly metabolize B12 so even if you're absorbing enough you can still be deficient.
Good overall health including good thyroid function and good liver function will play a role in proper enzyme function. I don't think the carnivore diet is the way to good health.
@jeremy
B12 deficiency is not normally caused by a lack of B12 in the diet. B12 absorption is complex and can easily be compromised. Supplements contain mega doses and some of it gets absorbed without instrinsic factor. As discussed above, proper enzyme function is required to properly metabolize B12 so even if you're absorbing enough you can still be deficient.
Good overall health including good thyroid function and good liver function will play a role in proper enzyme function. I don't think the carnivore diet is the way to good health.
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Quote from
Даниил on October 31, 2021, 10:57 am
@jeremy what I learned from the Russian segment of the Internet is that B12 malabsorption is seem to be common. For me personally, it seems that only cyancobalamin injections work (no even methyl sublingual supplements)
@jeremy what I learned from the Russian segment of the Internet is that B12 malabsorption is seem to be common. For me personally, it seems that only cyancobalamin injections work (no even methyl sublingual supplements)
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@jaj
If you're peeing it out, then you're not having an absorption problem. But you're right that you can't know whether your body is actually using what you absorb just by looking at how much you're peeing out. Like so many things, you might be able to ascertain a proof positive scenario but not a proof negative: if you consume a concentrated dose of B2 and you don't wind up with bright yellow urine, it's probably a reliable indicator that you're starved for B2; on the other hand, peeing out a bunch of B2 doesn't necessarily mean your body is functionally replete with it.
@jaj
If you're peeing it out, then you're not having an absorption problem. But you're right that you can't know whether your body is actually using what you absorb just by looking at how much you're peeing out. Like so many things, you might be able to ascertain a proof positive scenario but not a proof negative: if you consume a concentrated dose of B2 and you don't wind up with bright yellow urine, it's probably a reliable indicator that you're starved for B2; on the other hand, peeing out a bunch of B2 doesn't necessarily mean your body is functionally replete with it.
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Quote from
Ourania on October 31, 2021, 9:01 pm
@daniil I found the transdermal oil of Dr Greg work extremely well. b12oils
I wrote this in April #29
@daniil I found the transdermal oil of Dr Greg work extremely well. b12oils
I wrote this in April #29
Quote from
tim on September 11, 2023, 3:17 am
@luke
I've been doing some research trying to understand how ascorbate detoxifies retinoic acid. Maybe I'm wrong but I suspect that when taking supplemental amounts of ascorbate some ascorbate gets metabolized into glucuronate thus allowing dramatically increased glucuronidation of retinoic acid. Because kombucha can (depends on the batch and how it's brewed) contain large amounts of glucuronic acid I ended up searching for "kombucha" on this forum and came across your excellent post.
I have been drinking the energy drink V lately because it's an easy way to get supplemental taurine and riboflavin. What is really interesting is that it says it contains 63mg of glucuronolactone per can. Here in Australia Red Bull doesn't seem to contain it. V seems like the perfect beverage for recovering from Hypervitaminosis A haha.
@luke
I've been doing some research trying to understand how ascorbate detoxifies retinoic acid. Maybe I'm wrong but I suspect that when taking supplemental amounts of ascorbate some ascorbate gets metabolized into glucuronate thus allowing dramatically increased glucuronidation of retinoic acid. Because kombucha can (depends on the batch and how it's brewed) contain large amounts of glucuronic acid I ended up searching for "kombucha" on this forum and came across your excellent post.
I have been drinking the energy drink V lately because it's an easy way to get supplemental taurine and riboflavin. What is really interesting is that it says it contains 63mg of glucuronolactone per can. Here in Australia Red Bull doesn't seem to contain it. V seems like the perfect beverage for recovering from Hypervitaminosis A haha.
Quote from
tim on September 11, 2023, 3:31 am
The resulting oxidized form, DHA is either recycled by several processes that are described below or is converted into 2,3-diketo-l-gulonic acid, which is then further metabolized via l-xylose, l-threonic acid plus oxalic acid, or l-xylonic acid and l-lyxonic acid.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325764/
The studies I'm aware of that show that ascorbate detoxifies retinoic acid were done on rats. Because rats have L-Gulonolactone oxidase while humans don't it is much more likely that they will metabolize glucuronate from supplemental ascorbate. But if humans cannot metabolize glucuronate from AA then why does supplemental megadose ascorbate help during acute illness like viral infection?
The resulting oxidized form, DHA is either recycled by several processes that are described below or is converted into 2,3-diketo-l-gulonic acid, which is then further metabolized via l-xylose, l-threonic acid plus oxalic acid, or l-xylonic acid and l-lyxonic acid.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325764/
The studies I'm aware of that show that ascorbate detoxifies retinoic acid were done on rats. Because rats have L-Gulonolactone oxidase while humans don't it is much more likely that they will metabolize glucuronate from supplemental ascorbate. But if humans cannot metabolize glucuronate from AA then why does supplemental megadose ascorbate help during acute illness like viral infection?
Quote from
Viktor2 on September 23, 2023, 5:19 am
Quote from
tim on September 11, 2023, 3:31 am
But if humans cannot metabolize glucuronate from AA then why does supplemental megadose ascorbate help during acute illness like viral infection?
Well, does it? AFAIK only Zinc helps with acute infections, VitC didn't shorten healing time in scientific studies.
Quote from
tim on September 11, 2023, 3:31 am
But if humans cannot metabolize glucuronate from AA then why does supplemental megadose ascorbate help during acute illness like viral infection?
Well, does it? AFAIK only Zinc helps with acute infections, VitC didn't shorten healing time in scientific studies.
Quote from
tim on September 23, 2023, 9:42 pm
@viktor2 wrote:
Well, does it? AFAIK only Zinc helps with acute infections, VitC didn't shorten healing time in scientific studies.
For which virus? In general vitamin C appears to reduce infection duration and severity.
It makes sense since viral infections can cause significant enough transient Hypervitaminosis A to cause symptoms like bleeding gums. The increase in collagen turnover depletes vitamin C.
@viktor2 wrote:
Well, does it? AFAIK only Zinc helps with acute infections, VitC didn't shorten healing time in scientific studies.
For which virus? In general vitamin C appears to reduce infection duration and severity.
It makes sense since viral infections can cause significant enough transient Hypervitaminosis A to cause symptoms like bleeding gums. The increase in collagen turnover depletes vitamin C.
Quote from
Viktor2 on September 24, 2023, 12:21 pm
At least about the common cold I've read again and again that no studies could prove any benefit of taking vC, but taking Zinc after onset of symptoms (not general supplementation for some reason) shortened time of sickness by one day.
Have you read different things about vC, @tim-2? Or only regarding other viruses?
That said, what you wrote intuitively makes sense to me, so I might try to ingest more vC regardless of what I've read about colds.
At least about the common cold I've read again and again that no studies could prove any benefit of taking vC, but taking Zinc after onset of symptoms (not general supplementation for some reason) shortened time of sickness by one day.
Have you read different things about vC, @tim-2? Or only regarding other viruses?
That said, what you wrote intuitively makes sense to me, so I might try to ingest more vC regardless of what I've read about colds.
Quote from
tim on September 24, 2023, 6:44 pm
@viktor2
Vitamin C in the Prevention and Treatment of the Common Cold
Meta-analyses have summarized the evidence from numerous trials conducted after the release of Pauling’s book. A systematic review by Hemilä and Chalker2 included 63 placebo-controlled trials, 4 of which were included in Pauling’s original research, to help answer the question as to whether vitamin C reduces the incidence, duration, or severity of the common cold when used as daily supplementation or at the onset of cold symptoms. The review analyzed 29 trial comparisons on the preventive effects of regularly administered vitamin C. Regularly administered is defined as vitamin C administered daily during the study period regardless of presence of cold symptoms. The results from the analysis of these studies indicated that for the general population, vitamin C supplementation given at doses ≥0.2 g/day had no effect on the number of people who catch the common cold (relative risk = 0.97; 95% confidence interval = 0.94-1.00).2 Interestingly, a subgroup analysis found that regular vitamin C supplementation in persons under high physical stress (marathon runners, skiers, and soldiers) decreased the incidence of the common cold by 50%.2
While regularly administered vitamin C did not seem to affect the incidence of the common cold in the general population, the review also analyzed 31 comparisons on the effect of regular vitamin C supplementation on symptom duration and severity of colds. The results indicated that regular vitamin C supplementation (at an average dose of 1-2 g/day) resulted in a significant reduction in the duration of common colds, an 8% reduction for adults and 14% reduction for children. The severity of cold symptoms was also reduced. However, a variety of measures were used to classify severity in the studies and it is thus difficult to further define this finding.
@viktor2
Vitamin C in the Prevention and Treatment of the Common Cold
Meta-analyses have summarized the evidence from numerous trials conducted after the release of Pauling’s book. A systematic review by Hemilä and Chalker2 included 63 placebo-controlled trials, 4 of which were included in Pauling’s original research, to help answer the question as to whether vitamin C reduces the incidence, duration, or severity of the common cold when used as daily supplementation or at the onset of cold symptoms. The review analyzed 29 trial comparisons on the preventive effects of regularly administered vitamin C. Regularly administered is defined as vitamin C administered daily during the study period regardless of presence of cold symptoms. The results from the analysis of these studies indicated that for the general population, vitamin C supplementation given at doses ≥0.2 g/day had no effect on the number of people who catch the common cold (relative risk = 0.97; 95% confidence interval = 0.94-1.00).2 Interestingly, a subgroup analysis found that regular vitamin C supplementation in persons under high physical stress (marathon runners, skiers, and soldiers) decreased the incidence of the common cold by 50%.2
While regularly administered vitamin C did not seem to affect the incidence of the common cold in the general population, the review also analyzed 31 comparisons on the effect of regular vitamin C supplementation on symptom duration and severity of colds. The results indicated that regular vitamin C supplementation (at an average dose of 1-2 g/day) resulted in a significant reduction in the duration of common colds, an 8% reduction for adults and 14% reduction for children. The severity of cold symptoms was also reduced. However, a variety of measures were used to classify severity in the studies and it is thus difficult to further define this finding.
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