Discussion

I needed to disable self-signups because I’ve been getting too many spam-type sign-ups lately. Please contact me directly if you want membership on this forum. Thanks.

Forum Navigation
Please to create posts and topics.

How does Accutane work?

@jiri

I'm always looking to find the cause but H2O2 has been a life saver for me with seb derm until I found out about vA. It may be more trouble than it is worth for acne but it could be very helpful.

Quote from Jiří on June 27, 2020, 12:27 am

@tim-2 I tried and was prescribed EVERYTHING for acne. Nothing worked and I know for sure that putting something on the skin is not a solution. You need to address the cause of the acne and heal the skin from the inside out. All this you need to wash your face etc.. Every time I dried my skin the oil production and irritation and the acne was worse. I would never ever recommend to someone putting something on their skin other than water. I would recommend good healthy life style and diet for sure. Because that will help EVERYONE like at least 50%. After that they need to find out if they have some toxicity, damaged gut walls for some reason etc.. I would love to travel back in time and said this to me when I was 14yo. My life would be completely different now.. 

Same @jiri only if I knew what I knew now, and could tell 14yr old me the goods as well.

Like Jifi, I put very very little on my face anymore.  Trad soap, water, sunshine.  Something I allow now is a little gentle scratching.  If a scratching session gets out of control, a little self hypnosis.  

Here’s an interesting report on accutane causing diabetes.

They claim that the disease was latently sitting there just waiting to be “unmasked” by accutane.  There appears to be no end to the BS excuses used to protect this horrible drug and distract from the obvious conclusion. No, it didn’t “unmask” the disease - it caused the disease.

https://care.diabetesjournals.org/content/32/8/e99

Association Between Oral Isotretinoin Therapy and Unmasked Latent Immuno-Mediated Diabetes

Nonetheless, in addition to all the other “auto-immune” conditions reported post accutane use, I think it’s good evidence that high-dose vA (via accumulation or other) is at the root cause of diabetes too. 

 

Quote from ggenereux on June 29, 2020, 10:50 am

.. in addition to all the other “auto-immune” conditions reported post accutane use ..

 

Absolutely, their "auto-immune" theory doesn't make any sense  . Years ago I noticed that some people in rosacea community wished to label it as an auto-imune disease, though it's not like that would help to understand it better or find a cure.

@orion

Effect of Oral Isotretinoin Treatment on Skin Androgen Receptor Levels in Male Acneic Patients

Abstract
An oral daily dose (mean +/- SD, 0.75 +/- 0.05 mg/kg) of isotretinoin was administered for 3 months to six male patients with acne (scores of 4 and 5 according to Rosenfield). The therapy resulted in complete resolution of acne in four patients and improved acne significantly (score 1) in two patients. In accordance with recent findings, no change in serum testosterone and significant decreases in 5 alpha-dihydrotestosterone, 5 alpha-androstane-3 alpha,17 beta-diol glucosiduronate, and androsterone glucosiduronate levels were observed after treatment. Androgen receptor status was investigated in back skin biopsies obtained in acne areas before and after 3 months of isotretinoin treatment. The treatment did not modify the binding affinity constant of skin androgen receptor (0.44 vs. 0.32 nmol/L), but it did induce a 2.6-fold decrease in its binding capacity constant (62 vs. 24 fmol/mg cytosolic protein), as assessed by Scatchard plot and confirmed immunologically by Western blot analysis. These data clearly showed that skin androgen receptor was sensitive to oral isotretinoin administration in acneic patients. The decrease in skin androgen receptor levels (this study) and the recently reported suppression of skin 5 alpha-dihydrotestosterone production by isotretinoin treatment appeared consistent with the involvement of androgen receptor and 5 alpha-dihydrotestosterone in the pathogenesis of acne. Indeed, sebum production is under androgen control, and an abnormal response of the pilosebaceous unit to androgens appears to be implicated in the pathogenesis of acne. These observations were consistent with the absence of sebum in complete androgen-insensitive patients and normal sebum production in male pseudohermaphrodites.

https://pubmed.ncbi.nlm.nih.gov/7714084/

Perhaps Hypervitaminosis A induces oily skin due to not enough 13-cis-retinoic acid being produced to inhibit 5 alpha-reductase significantly while simultaneously promoting 5 alpha-reductase? ATRA competes with VDRs and Vitamin D inhibits oily skin. Zinc inhibits 5 alpha-reductase so Hypervitaminosis A depleting zinc is another mechanism. There are probably others... 

Quote from tim on July 1, 2020, 12:21 am

Perhaps Hypervitaminosis A induces oily skin due to not enough 13-cis-retinoic acid being produced to inhibit 5 alpha-reductase significantly while simultaneously promoting 5 alpha-reductase? ATRA competes with VDRs and Vitamin D inhibits oily skin. Zinc inhibits 5 alpha-reductase so Hypervitaminosis A depleting zinc is another mechanism. There are probably others... 

@tim-2 Have experimented with all kinds of dosages of VitD and Zn, also sunbathing, no luck with respect to sebum flow.  Been searching for the answer for a decade.  Last hope is that getting VA out will do the job.

@orion

Studies have shown that both D and zinc help for most people but I'm like you, I haven't seen any benefit from them. Regardless I was thinking more of the mechanism behind Hypervitaminosis as opposed to Accutane. I think Hypervitaminosis really counteracts the effects of other nutrients to the point where one has to megadose like with pantothenic acid to see an effect. Meaning only vA depletion is the solution... heres hoping.

Quote from Jiří on June 27, 2020, 12:27 am

@tim-2 I tried and was prescribed EVERYTHING for acne. Nothing worked and I know for sure that putting something on the skin is not a solution. You need to address the cause of the acne and heal the skin from the inside out. All this you need to wash your face etc.. Every time I dried my skin the oil production and irritation and the acne was worse. I would never ever recommend to someone putting something on their skin other than water. I would recommend good healthy life style and diet for sure. Because that will help EVERYONE like at least 50%. After that they need to find out if they have some toxicity, damaged gut walls for some reason etc.. I would love to travel back in time and said this to me when I was 14yo. My life would be completely different now.. 

I have the same thing. All those popular things that I tried for acne, such as hydrogen peroxide, salicylic acid... It only caused irritation on my skin and did not help acne. So I'm sure the problem is inside. Perhaps this diet will solve the problem...

It was very interesting to re-read this thread now. I suspect that VA/accutane creates some kind of imbalance in the body and apparently someone is very far from this imbalance, and someone is close. However, I have not yet understood the specific mechanism of this. In my case, apparently, "fish oil" was the last straw or something like that. I wonder how to get everything back.