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Glycine - glyfosate - retinol connection
Quote from Liz on February 10, 2019, 4:57 amGuys, I need help to figure this out.
I remembered an old post at 180degreehealth by Joel Brind, who is, to put it mildly, very pro glycine supplementation.
I hadn'read it since it was published and going back ro re-read i cannot help to think there might be a connection between glycine deficiency and vitamin A based on all the positive findings Joel write about here (and at other places at 180d): http://180degreehealth.com/glycine-immune-system/ like, glycine helped reduce severe sunburn.
This one brings up pathways relevant for the Price article below: http://180degreehealth.com/diet-inflammation-part-4/
And then I stumbled over this, who seems at first focus on folic acid issues but then get more into depth with glycine - glyfosate - retinol (just ignore the dietary advice at the end for obvious reasons).
It seems as if glyfosate can "replace" glycine and to me this is a bit scary since glycine is a part of glutatione, the mother of all antioxidants.
I would love if anyone could help me dig a bit deeper to see if we can come to understand this a bit better. Glycine is (due to diet, or glyfosate, or both?) also more deficient these days as it occur most in skin and tendons and not in muscle meat hence an imbalance can more easily occur of one relies on muscle meat alone (or goes vegan).
Great stuff Liz, thanks for the link to Joel Brind. I just finished reading his article and the comments. Wow. I'll start looking at papers and see if I can find anything useful.
Liz said "my memory is horribly shitty still, and yet I have improved hugely. Thanks vit A, you a$$hole 
"
No worries Liz. I have a horrible memory all the time now and have had for a decade. My memory used to be really great - never kept a planner/schedule because I didn't need to. Now I forget really important things not to mention random posts and if I replied or not. People don't get that it isn't just an age thing, it is an accumulation thing.
Quote from Guest on February 11, 2019, 7:59 pmQuote from Liz on February 10, 2019, 4:57 amGuys, I need help to figure this out.
I remembered an old post at 180degreehealth by Joel Brind, who is, to put it mildly, very pro glycine supplementation.
I hadn'read it since it was published and going back ro re-read i cannot help to think there might be a connection between glycine deficiency and vitamin A based on all the positive findings Joel write about here (and at other places at 180d): http://180degreehealth.com/glycine-immune-system/ like, glycine helped reduce severe sunburn.
This one brings up pathways relevant for the Price article below: http://180degreehealth.com/diet-inflammation-part-4/
And then I stumbled over this, who seems at first focus on folic acid issues but then get more into depth with glycine - glyfosate - retinol (just ignore the dietary advice at the end for obvious reasons).
It seems as if glyfosate can "replace" glycine and to me this is a bit scary since glycine is a part of glutatione, the mother of all antioxidants.
I would love if anyone could help me dig a bit deeper to see if we can come to understand this a bit better. Glycine is (due to diet, or glyfosate, or both?) also more deficient these days as it occur most in skin and tendons and not in muscle meat hence an imbalance can more easily occur of one relies on muscle meat alone (or goes vegan).
Great stuff Liz, thanks for the link to Joel Brind. I just finished reading his article and the comments. Wow. I'll start looking at papers and see if I can find anything useful.
That would be very helpful Guest 🙂 I dont have the same study-reading stamina as I used to and there are a lot of sharp brains im here 🙂 . Just creating this post and finding the review study link knocked me dead 😂 (as in I fell asleep). Btw I think Brind did a 4-part glycine piece at 180d and it was the part 4 I posted. Very interesting comments and good questions too, I think 🙂
Quote from Guest on February 11, 2019, 9:55 pmLiz said "my memory is horribly shitty still, and yet I have improved hugely. Thanks vit A, you a$$hole
No worries Liz. I have a horrible memory all the time now and have had for a decade. My memory used to be really great - never kept a planner/schedule because I didn't need to. Now I forget really important things not to mention random posts and if I replied or not. People don't get that it isn't just an age thing, it is an accumulation thing.
Not to hijack my own thread, but I went through all years of school without studying and barely even paying attention during class, so I hear ya. After my study abroad year in HS (USA) my memory first started getting worse and it was horrible realizing I would need to start studying to make my grades. I remember noticing vitamins was added to everything, even cookies. But now what I read actually stuck so it was not that much of an issue, just annoying to lose some free time to school work. Fast forward 10 years after that and brain was like teflon . Could ask the same question 10 times in one hour with no memory of the answer or even that I had asked it. My life consisted of lists and postits covering my walls. Now additionaly 8 years later I have improved a LOT the last 2 years and even more the last 9 months. Memory got worse again after eating daily carrots at work and when I stopped that and all other high A veggies it is getting better slowly. I have hopes of getting my super brain back. The hope is the last thing that dies 😂
Liz,
I was similar to you in high school and college in regards to not needing to study. As long as I covered the material once by lecture or reading it was enough for me to get good grades. That all changed in my twenties (far too early) when I started retin-a and ‘healthy eating’! Fortunately I was able to earn a degree by that point that qualified me for a decent enough career to support my family. I didn’t like the work at all but stuck with it out of necessity.
I have been taking courses to change careers and the most wonderful thing happened this week. I just took my board exams and I passed on the first attempt. It’s a 50% pass rate. Everyone I spoke with before the test was retaking it. I was the second one finished too. We were allowed 4 hours to complete the test and I finished in 3. I truly think at age 49 my brain is working again like it did in my 20’s.
Hey Liz, I'm really impressed reading Joel's stuff. Presently in the middle of
https://www.sweetamine.com/the-breakthrough-science-of-sweetamine/index.html
One thing Joel mentioned about most people throwing away the bones and connective tissues of poultry and fish, the glycine parts, took me back to daily lunches with a buddy from Nigeria. He had a chicken leg almost every day, and gnawed the end like I'd never seen before. His grandfather was well-documented (obituary in the NY Times) to have lived 140 years. Ibitayo told me he ate simply; root vegetables, some fruits, a little meat. Can you imagine! I'm assuming the gnawing on the ends of chicken bones was deeply ingrained over thousands of years in their ancestral culture. His family also fasted one day a week on water. He was the peak of health and productivity.
Anyway, once I get a better drift on all things glycine via Joel, I'll see what kinds of search terms I can come up with to use on PubMed for nailing down a retinoid connection. Wouldn't that be interesting? Hang in there, collectively we can poke our heads out of the fog and low-hanging clouds. I bought some glycine today in town. Carlson's little 100 gram tubs. Looks like about a buck a day if following the 8 gram/day scenario.
Hey Bella, congrats on your success!
John
Thanks John, I might break out the collagen again. I love the ends on chicken legs. 🙂
bella
Wow, just scratching the surface on Glycine makes me really hopeful about it's potential. I think one of Dr. Joel Brind's major contributions is identifying an amount required for therapeutic effect - an unexpected 8 grams a day. I'd like to see more on that, but I'm giving it a go this coming week. This paper might help in the search for a retinoid connection, but even if it doesn't, the information seems to be essential. This is such basic, foundational stuff. It really reinforces Grant's caution about getting enough protein for sure. The liver-protection aspect alone is worth the price of admission! You know, this could be one of those things that if ignored, might slow down or impede the progress of going on a low-A diet, and the person lacking enough Glycine wouldn't have any idea of why they were having such a rough-go, if they hadn't run across the benefits of increasing their intake. It sounds like it should easily help people get over the bumps in the road and mitigate the detox flare-ups.
The whole article is available at
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855430/
Hope it's OK to put this over under PubMed papers too.
Dietary Glycine Is Rate-Limiting for Glutathione Synthesis and May Have Broad Potential for Health Protection.
Abstract
Background:
Glutathione is a key scavenging antioxidant that opposes the proinflammatory signaling of hydrogen peroxide. Boosting cellular glutathione levels may have broad utility in the prevention and treatment of disorders driven by oxidative stress. Supplemental N-acetylcysteine has been employed for this purpose. Could supplemental glycine likewise promote glutathione synthesis?
Methods:
We conducted a review of the pertinent literature using PubMed.
Results:
Tissue glycine levels are lower than the glutathione synthase Michaelis constant (Km) for glycine. When glycine availability is too low to sustain a normal rate of glutathione synthesis, the consequent rise in tissue levels of gamma-glutamylcysteine leads to an increase in urinary excretion of its alternative metabolite 5-L-oxoproline. The fact that urinary excretion of this metabolite is elevated in vegetarians and others consuming relatively low-protein diets strongly suggests that dietary glycine can be rate-limiting for glutathione synthesis in normally fed humans. Moreover, supplemental glycine has been reported to increase tissue glutathione levels in several animal studies. Glycine is a biosynthetic precursor for porphyrins, purines, creatine, sarcosine, and bile salts; is an agonist for glycine-gated chloride channels and a coagonist for N-methyl-D-aspartate receptors; inhibits protein glycation; and increases hepatic production of pyruvate, an effective scavenger of hydrogen peroxide. Supplemental glycine may have the potential for improving endothelial function, preventing cardiac hypertrophy, aiding control of metabolic syndrome, preventing the complications of diabetes, dampening inflammation, protecting the liver, and promoting effective sleep.
Conclusion:
Clinical research is warranted to evaluate the impact of supplemental glycine on glutathione levels and on various health disorders.
Whoa, just re-read that. Glycine is a precursor for bile salts. Could that be a useful retinoid connection?