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Influence of food on ADH and ALDH activity
Quote from Janelle525 on January 2, 2024, 8:05 amQuote from El on January 2, 2024, 4:47 amThe cure for all diseases is to eat foods high in cysteine, and foods that greatly increase aldh and lower adh. adh increases acetylhadeide. every disease in the body a lot of acetyladeid accumulated. Beans lower adh, but also adlh. I don't think it's the solutionIf beans didn't work at all Grant wouldn't have gotten his life back. Nor would the lady with ulcerative colitis (which by the way she just posted a good podcast for the ladies https://www.youregreat.com/blog/2023/12/22/karen-hurd-peri-menopause ). If I started eating beans I would be in pain every 5 days on the toilet. I need to go about it a different way, but I acknowledge that they have worked for many people no matter what a study may say (I really hate studies that claim a food does one thing in the body for all people- one person's medicine may be another's poison).
Grant had his greatest improvement the first year of the diet. For the first year I didn't eat beans.
Quote from Janelle525 on January 2, 2024, 9:10 amGarrett Smith responded to the pear thing:
"There are good and bad issues with pears. They are high in pectin soluble fiber, which is good. A big issue is that as pears ripen, they make a decent amount of formaldehyde. This is why overly ripe pears often bother people’s digestion. Asian pears (the ones you are talking about) seem to make even more formaldehyde than others. This is why the body speeds up ADH and ALDH, because there are more toxins present I would not purposely increase (overly ripe) pear intake to try to speed detox. Some people in my group tried doing this in the past, it didn’t end well and proved my point."
Here in the forum there are people who eat pears and are cured. Pears suit me very well. I said the beans are not bad. All fruits have formaldehyde, apples have a lot of it and lower ADLH, what Smith says doesn't make sense. If the adlh rises due to formaldehyde, it would rise with the apples. and apples lower the adlh a lot
Quote from Inger on January 2, 2024, 8:17 amQuote from El on January 2, 2024, 4:47 amThe cure for all diseases is to eat foods high in cysteine, and foods that greatly increase aldh and lower adh. adh increases acetylhadeide. every disease in the body a lot of acetyladeid accumulated. Beans lower adh, but also adlh. I don't think it's the solutionSo how about nuts, do they increase ALDH/lower ADH?
I could easily eat a couple pears every day, I love pears, always did! But I see great benefits from including beans in my diet. I would guess, because i eat a lot of meat and onions too, the bans will not disturb the healing of my body, but carry out toxic bile and help healing. I really need the beans to heal my gallbladder because it was full of thick bile and probably stones and sludge I am so sure. Also my hormones are balancing with the beans.. I can feel it.
@el have you tried to eat your diet with meat and pears etc and also include a small amount of beans, if there is any negative or positive impact?
I am also wondering about fermented beans. I have eaten several spoonful of my home fermented beans every day the last weeks and I really like the taste.
When I introduce beans, my liver enzymes get worse.
"
When I introduce beans, my liver enzymes get worse.
"
@el, but how do they make you feel, and did you start slow or did you ate a lot in the beginning? I wonder if only looking at bloodwork sometimes can not tell the whole thing because sometimes healing makes bloodwork go wonky donky.
I do believe there might people beans are not good for and especially they do increase detox, but what I also do know is we must be very well adapted to them as they have been a staple food all over the earth for thousands of years.
Quote from Inger on January 2, 2024, 9:47 am"
When I introduce beans, my liver enzymes get worse."
@el, but how do they make you feel, and did you start slow or did you ate a lot in the beginning? I wonder if only looking at bloodwork sometimes can not tell the whole thing because sometimes healing makes bloodwork go wonky donky.
I do believe there might people beans are not good for and especially they do increase detox, but what I also do know is we must be very well adapted to them as they have been a staple food all over the earth for thousands of years.
Most tribes around the world remove soluble fiber from their foods. They only eat insoluble fiber. That thing about always eating fiber is a myth.
Quote from El on January 2, 2024, 9:51 amQuote from Inger on January 2, 2024, 9:47 am"
When I introduce beans, my liver enzymes get worse."
@el, but how do they make you feel, and did you start slow or did you ate a lot in the beginning? I wonder if only looking at bloodwork sometimes can not tell the whole thing because sometimes healing makes bloodwork go wonky donky.
I do believe there might people beans are not good for and especially they do increase detox, but what I also do know is we must be very well adapted to them as they have been a staple food all over the earth for thousands of years.
Most tribes around the world remove soluble fiber from their foods. They only eat insoluble fiber. That thing about always eating fiber is a myth.
You may have that backwards. It's only possible to separate insoluble fiber such as the outer bran of grains. Tribes have been known to even separate the fiber from root crops. That would leave only what's soluble in the food.
Quote from El on January 2, 2024, 9:31 amQuote from Janelle525 on January 2, 2024, 9:10 amGarrett Smith responded to the pear thing:
"There are good and bad issues with pears. They are high in pectin soluble fiber, which is good. A big issue is that as pears ripen, they make a decent amount of formaldehyde. This is why overly ripe pears often bother people’s digestion. Asian pears (the ones you are talking about) seem to make even more formaldehyde than others. This is why the body speeds up ADH and ALDH, because there are more toxins present I would not purposely increase (overly ripe) pear intake to try to speed detox. Some people in my group tried doing this in the past, it didn’t end well and proved my point."
Here in the forum there are people who eat pears and are cured. Pears suit me very well. I said the beans are not bad. All fruits have formaldehyde, apples have a lot of it and lower ADLH, what Smith says doesn't make sense. If the adlh rises due to formaldehyde, it would rise with the apples. and apples lower the adlh a lot
He was referring to overly ripe fruit. I don't think anyone will eat an apple that is overly ripe, pears on the other hand need to be very ripe to even taste good which means you leave them sit out for long periods of time. I rarely buy pears for this reason even though I do like a good ripe pear, they just don't taste good unless ripe enough. But if they work for you great! I am being cautious with fruit due to the methanol in the pectin releasing formaldehyde the longer it ripens on the counter and also the longer it sits in a bottle or can. Tomatoes in a can being the worst. (simmer tomato sauces for 3 hours with lid partially open) Bananas are the fruit that works best for me. I have been trying not to eat them overly ripe anymore. Good thing is any wasted bananas goes to feed the bananas I grow in my yard.
For anyone interested in more info about methanol and fruits and veggies: http://www.whilesciencesleeps.com/
He does claim the bottled and canned have far more than fresh fruit and veggies. But I do think we need to be cautious with overly ripe fruit.
I think I am having poor sleep/restless legs from seltzer. I'm going to stop that and will report if that was it.
The first step in alcohol metabolism consists of the oxidation in the liver of alcohol (ethanol or C2H6O), which, when oxidized, is transformed into acetaldehyde by ADH. This acetaldehyde will also be oxidized, giving rise to acetate by the action of ALDH. In extrahepatic tissues, acetate is oxidized requiring Acetyl CoA, a key molecule for cellular metabolism, establishing a connection with the Krebs cycle and cellular energy production. As a result of these oxidations, there is an accumulation of NADH and a relative deficiency of the coenzyme NAD, which is transformed into NADH (the same thing that occurred in the alcoholic fermentation of yeasts). This alteration of the NADH/NAD+ ratio, in turn, causes a series of inhibitions in other metabolic pathways, causing, globally and in cases of chronic alcoholism, states of metabolic acidosis, hypoglycemia (not as much glucose is formed through gluconeogenesis). hypertriglyceridemia, hyperlipoproteinemia (lipogenesis is enhanced), hypoproteinemia, hypovitaminosis (especially of vitamin B12 and B1) and increased diuresis. All these reactions of alcohol metabolism occur at a constant rate approximately equivalent to one drink per hour; If this relationship is altered, the metabolism of alcohol is modified, causing a series of harmful effects on the body or even, on the percentage that is eliminated through urine, sweat and exhaled air, an accumulation due to its inhibition. The reasons why these effects occur are:
– the oxidation pathway mediated by the enzymes ADH and ALDH becomes less efficient, causing the MEOS oxidation pathway (microsomal ethanol oxidation system in the smooth endoplasmic reticulum) to be activated. The activation of this pathway, predominant in people with chronic alcohol consumption, causes the liver to metabolize alcohol more efficiently, causing blood alcohol levels to increase more slowly, but on the other hand, it triggers greater metabolic tolerance. to alcohol (larger quantities of alcohol are needed to generate effects on the body). The activation of this oxidation pathway also has an impact on the greater effect of certain drugs when ingesting alcoholic beverages, since the MEOS pathway, the main degradation and detoxification pathway of xenobiotics, gives priority to the oxidation of alcohol over the metabolization of drugs, causing the latter to accumulate and remain in the blood circulation, intensifying their pharmacological effect (e.g. certain antibiotics can inhibit the activity of the ADH enzyme)
Alcohol (ethanol) is itself a toxin, but it is not the only one, since acetaldehyde also produces a series of harmful effects such as inhibition of protein synthesis, increased production of free radicals and peroxidation. (oxidative degradation) of lipids and other organic compounds. The greater or lesser degree of acetaldehyde accumulation depends on the relative activity of the ADH and ALDH enzymes. This is well observed in the case of population ethnicities of Asian origin, whose individuals present relatively normal ADH activity indices while ALDH activity indices are relatively low (enzyme synthesized from the expression of the ALDH2 allele); This imbalance between the activity rates of the enzymes leads people who have ALDH from the ALDH2 allele to accumulate more acetaldehyde, which causes, even when alcohol consumption is low, a series of symptoms such as redness of the face, nausea, tachycardia or hyperventilation.
· Can you determine if a person has recently drunk alcohol on a regular basis with a blood test?
Yes, and this is where GGTP (gamma glutamyl transpeptidase or gamma glutamyl transferase) intervenes, an enzyme present in liver microsomes and in plasma membranes of other tissues such as: kidneys, bile duct, pancreas, spleen, heart, brain and seminal vesicles. This enzyme is responsible for catalyzing the transfer reaction of the glutamyl group to a substrate (water, some L-amino acids and peptides), of amino acids through the plasma membrane, as well as, it also plays an important role in the synthesis and degradation of glutathione or detoxification of drugs and xenobiotics.