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Lactoferrin
Quote from
Jiří on November 15, 2021, 1:56 am
Quote from
Jenny on November 14, 2021, 2:00 pm
It is. I don’t know how much Garrett Smith is charging. From the evidence I’ve seen so far there is a difference in people’s reactions between the lactoferrin extracted from milk and the cheaper products, but I don’t understand why. I only tried the Life Extension one not the Jarrow so I don’t have personal experience of that one. I can’t really understand why there should be a difference, but I’m just reporting what I’ve heard so that people can be cautious if they want to be.
Lactoferrin should kill bad bacteria right. So that means a lot of endotoxin during that time. So it should be expected to feel not so good while taking it. If you don't feel anything maybe it doen't work...
Quote from
Jenny on November 14, 2021, 2:00 pm
It is. I don’t know how much Garrett Smith is charging. From the evidence I’ve seen so far there is a difference in people’s reactions between the lactoferrin extracted from milk and the cheaper products, but I don’t understand why. I only tried the Life Extension one not the Jarrow so I don’t have personal experience of that one. I can’t really understand why there should be a difference, but I’m just reporting what I’ve heard so that people can be cautious if they want to be.
Lactoferrin should kill bad bacteria right. So that means a lot of endotoxin during that time. So it should be expected to feel not so good while taking it. If you don't feel anything maybe it doen't work...
Quote from
Jenny on November 15, 2021, 3:10 am
Good point @jiri. On the webinar I posted, the NT mentioned some people feeling off for a ‘couple of days’ but apart from that the general population don’t seem to get a negative reaction. A friend went through the Amazon reviews and didn’t see much negative (maybe that doesn’t realistically reflect). However, people on the vA detox seemed to have many more negative reactions, at least to the Life Extension brand. I don’t know why. Those of us on the detox for longer seemed to have the worst reactions.
Good point @jiri. On the webinar I posted, the NT mentioned some people feeling off for a ‘couple of days’ but apart from that the general population don’t seem to get a negative reaction. A friend went through the Amazon reviews and didn’t see much negative (maybe that doesn’t realistically reflect). However, people on the vA detox seemed to have many more negative reactions, at least to the Life Extension brand. I don’t know why. Those of us on the detox for longer seemed to have the worst reactions.
Quote from
Hermes on November 15, 2021, 12:47 pm
Quote from
Jiří on November 13, 2021, 11:16 pm
@jaj wow that's expensive in comparison with Jarrow which is good brand..
Garrett's Lactoferrin costs $ 55.95. The bottle comes with 30 capsules filled with 400 mg Lactoferrin each, so it totally amounts to 12 grams. The per gram price is pretty steep: 4.66. It gets particularly pricey for people who want to supplement it long-term. Lactoferrin.co offers pure bulk Lactoferrin, which seems legit, they list all sorts of labels whose requirements they pass. The per gram price comes down to $ 1.86 (buying 100 g) and reaches even $ 1.35 when choosing to buy 500 g bulk.
Quote from
Jiří on November 13, 2021, 11:16 pm
@jaj wow that's expensive in comparison with Jarrow which is good brand..
Garrett's Lactoferrin costs $ 55.95. The bottle comes with 30 capsules filled with 400 mg Lactoferrin each, so it totally amounts to 12 grams. The per gram price is pretty steep: 4.66. It gets particularly pricey for people who want to supplement it long-term. Lactoferrin.co offers pure bulk Lactoferrin, which seems legit, they list all sorts of labels whose requirements they pass. The per gram price comes down to $ 1.86 (buying 100 g) and reaches even $ 1.35 when choosing to buy 500 g bulk.
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Quote from
Jiří on November 16, 2021, 7:15 am
So lactoferrin is here. Ehm no lactoferrin, but APOlactoferrin.. They had misleading photos on e shop.. But maybe it will be even better version. It's synthetic form and it should be also antiviral not just antibacterial... https://cz.iherb.com/pr/jarrow-formulas-lactoferrin-freeze-dried-250-mg-60-capsules/134?gclid=Cj0KCQiAys2MBhDOARIsAFf1D1e7qAtK7ZMMNTcT9VZNOc36GZTPc7JWY-oCr8xq2FWvFp4fZ_6pf9AaApXOEALw_wcB&gclsrc=aw.ds
So lactoferrin is here. Ehm no lactoferrin, but APOlactoferrin.. They had misleading photos on e shop.. But maybe it will be even better version. It's synthetic form and it should be also antiviral not just antibacterial... https://cz.iherb.com/pr/jarrow-formulas-lactoferrin-freeze-dried-250-mg-60-capsules/134?gclid=Cj0KCQiAys2MBhDOARIsAFf1D1e7qAtK7ZMMNTcT9VZNOc36GZTPc7JWY-oCr8xq2FWvFp4fZ_6pf9AaApXOEALw_wcB&gclsrc=aw.ds
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Quote from
clare on November 16, 2021, 9:51 am
I am about to order that same one by Jarrow
I am about to order that same one by Jarrow
Quote from
Hermes on November 16, 2021, 12:02 pm
A great anecdote by someone who raves about lactoferrin and mentions how health improved significantly after supplementing with it. He describes it as a normal feeling of health he hasn't experienced in years. He feels less tired. And an injured finger healed afterwards and showed reduced inflammation. It seems as if lactoferrin works systemically and affects many different parts of the body. Now, that's a very good sign that lactoferrin works on multiple systems in the body. Here's the link to the story: https://raypeatforum.com/community/threads/lactoferrin-is-awesome.27831/
Here's another story from a ME/CFS community. Initially the lactoferrin helped to improve gut symptoms and then after three days other problems went away like joint pain. And the author "rediscovered the old self". Eventually the effects faded. Maybe the lactoferrin needs to be pulsed is the conclusion of the forum post. Here's the post (the following discussion is interesting too): https://forums.phoenixrising.me/threads/pulsing-lactoferrin.44450/
Lactoferrin could raise endotoxin when it helps the body clear excess bacteria, this could be experienced as worsening of symptoms. So that would be interesting to see in people who struggle with SIBO, like myself. I've ordered lactoferrin and expect it soon. I'm curious how it will affect me now that I have been on the low vitamin A diet for more than two years.
A great anecdote by someone who raves about lactoferrin and mentions how health improved significantly after supplementing with it. He describes it as a normal feeling of health he hasn't experienced in years. He feels less tired. And an injured finger healed afterwards and showed reduced inflammation. It seems as if lactoferrin works systemically and affects many different parts of the body. Now, that's a very good sign that lactoferrin works on multiple systems in the body. Here's the link to the story: https://raypeatforum.com/community/threads/lactoferrin-is-awesome.27831/
Here's another story from a ME/CFS community. Initially the lactoferrin helped to improve gut symptoms and then after three days other problems went away like joint pain. And the author "rediscovered the old self". Eventually the effects faded. Maybe the lactoferrin needs to be pulsed is the conclusion of the forum post. Here's the post (the following discussion is interesting too): https://forums.phoenixrising.me/threads/pulsing-lactoferrin.44450/
Lactoferrin could raise endotoxin when it helps the body clear excess bacteria, this could be experienced as worsening of symptoms. So that would be interesting to see in people who struggle with SIBO, like myself. I've ordered lactoferrin and expect it soon. I'm curious how it will affect me now that I have been on the low vitamin A diet for more than two years.
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Quote from
Hermes on November 16, 2021, 12:16 pm
And here two exciting studies covering the effects of lactoferrin on LPS (the debris released when bacteria die):
Lactoferrin-lipopolysaccharide (LPS) binding as key to antibacterial and antiendotoxic effects [Link]
ABSTRACT:
Lactoferrin (Lf), a multifunctional protein of the innate immune response, seems to act as a permeabilizing agent of Gram negative bacteria, apparently due to its interaction with enterobacterial lipopolysaccharide (LPS) on the bacterial surface. In both human and bovine Lf, a six residue sequence lying in an 18-loop region of the lactoferricin domain is key to Lf-LPS binding. There is much evidence that, by its action on LPS, Lf destabilizes the bacterial membrane and therefore increases bacterial permeability. By itself, Lf is not an effective antibacterial agent, but it permits the penetration of the bacterial membrane by some antibacterial substances whose hydrophobicity otherwise limits their efficacy. Additionally, Lf neutralizes free LPS by keeping the latter from forming complexes that activate TLR-4 signaling pathways. Such pathways, when over-activated, lead to the abundant production of pro-inflammatory mediators such as tumor necrosis factor (TNF) with fatal consequences to the host. The effect of Lf in reducing inflammation and destabilizing Gram negative bacteria has clinical implications in the control of sepsis, multiple organ dysfunction and bacterial invasion.
***
Lactoferrin Inhibits the Lipopolysaccharide-Induced Expression and Proteoglycan-Binding Ability of Interleukin-8 in Human Endothelial Cells [Link]
ABSTRACT:
Interleukin-8 (IL-8), a C-X-C chemokine bound to endothelium proteoglycans, initiates the activation and selective recruitment of leukocytes at inflammatory foci. We demonstrate that human lactoferrin, an antimicrobial lipopolysaccharide (LPS)-binding protein, decreases both IL-8 mRNA and protein expression induced by the complex Escherichia coli 055:B5 LPS/sCD14 in human umbilical vein endothelial cells. The use of recombinant lactoferrins mutated in the LPS-binding sites indicates that this inhibitory effect is mediated by an interaction of lactoferrin with LPS and CD14s that suppresses the endotoxin biological activity. Furthermore, since dimeric IL-8 and lactoferrin are both proteoglycan-binding molecules, the competition between these proteins for heparin binding was investigated. Lactoferrin strongly inhibited the interaction of radiolabeled IL-8 to immobilized heparin, whereas a lactoferrin variant lacking the amino acid residues essential for heparin binding was not inhibitory. Moreover, this process is specific, since serum transferrin, a glycoprotein whose structure is close to that of lactoferrin, did not prevent the interaction of IL-8 with heparin. These results suggest that the anti-inflammatory properties of lactoferrin during septicemia are related, at least in part, to the regulation of IL-8 production and also to the ability of lactoferrin to compete with chemokines for their binding to proteoglycans.
And here two exciting studies covering the effects of lactoferrin on LPS (the debris released when bacteria die):
Lactoferrin-lipopolysaccharide (LPS) binding as key to antibacterial and antiendotoxic effects [Link]
ABSTRACT:
Lactoferrin (Lf), a multifunctional protein of the innate immune response, seems to act as a permeabilizing agent of Gram negative bacteria, apparently due to its interaction with enterobacterial lipopolysaccharide (LPS) on the bacterial surface. In both human and bovine Lf, a six residue sequence lying in an 18-loop region of the lactoferricin domain is key to Lf-LPS binding. There is much evidence that, by its action on LPS, Lf destabilizes the bacterial membrane and therefore increases bacterial permeability. By itself, Lf is not an effective antibacterial agent, but it permits the penetration of the bacterial membrane by some antibacterial substances whose hydrophobicity otherwise limits their efficacy. Additionally, Lf neutralizes free LPS by keeping the latter from forming complexes that activate TLR-4 signaling pathways. Such pathways, when over-activated, lead to the abundant production of pro-inflammatory mediators such as tumor necrosis factor (TNF) with fatal consequences to the host. The effect of Lf in reducing inflammation and destabilizing Gram negative bacteria has clinical implications in the control of sepsis, multiple organ dysfunction and bacterial invasion.
***
Lactoferrin Inhibits the Lipopolysaccharide-Induced Expression and Proteoglycan-Binding Ability of Interleukin-8 in Human Endothelial Cells [Link]
ABSTRACT:
Interleukin-8 (IL-8), a C-X-C chemokine bound to endothelium proteoglycans, initiates the activation and selective recruitment of leukocytes at inflammatory foci. We demonstrate that human lactoferrin, an antimicrobial lipopolysaccharide (LPS)-binding protein, decreases both IL-8 mRNA and protein expression induced by the complex Escherichia coli 055:B5 LPS/sCD14 in human umbilical vein endothelial cells. The use of recombinant lactoferrins mutated in the LPS-binding sites indicates that this inhibitory effect is mediated by an interaction of lactoferrin with LPS and CD14s that suppresses the endotoxin biological activity. Furthermore, since dimeric IL-8 and lactoferrin are both proteoglycan-binding molecules, the competition between these proteins for heparin binding was investigated. Lactoferrin strongly inhibited the interaction of radiolabeled IL-8 to immobilized heparin, whereas a lactoferrin variant lacking the amino acid residues essential for heparin binding was not inhibitory. Moreover, this process is specific, since serum transferrin, a glycoprotein whose structure is close to that of lactoferrin, did not prevent the interaction of IL-8 with heparin. These results suggest that the anti-inflammatory properties of lactoferrin during septicemia are related, at least in part, to the regulation of IL-8 production and also to the ability of lactoferrin to compete with chemokines for their binding to proteoglycans.
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Quote from
Orion on November 16, 2021, 3:24 pm
Started with 50mg pure lactoferrin tonight, think I will go for 100mg/day depending how this goes tonight, my sleep cycles are delicate, hoping for a non insomnia like side effect.
Also started with FC-Cidal last week as another biome modifier, so far no negatives, so hopefully helping, planning to take one a day for 2 months(full bottle). @tim-2
Started with 50mg pure lactoferrin tonight, think I will go for 100mg/day depending how this goes tonight, my sleep cycles are delicate, hoping for a non insomnia like side effect.
Also started with FC-Cidal last week as another biome modifier, so far no negatives, so hopefully helping, planning to take one a day for 2 months(full bottle). @tim-2
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Quote from
Jiří on November 16, 2021, 10:32 pm
I started yesterday with 2x250mg capsulses. Will take 2x250mg two times a day. I have two 60caps bottles so it's 30 day supply. Will see if it does anything..
I started yesterday with 2x250mg capsulses. Will take 2x250mg two times a day. I have two 60caps bottles so it's 30 day supply. Will see if it does anything..
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Quote from
Katrina on November 17, 2021, 9:23 am
Jarrow brand has Apolactoferrin which has slightly different mechanism of action than lactoferrin. Both can be derived similarly from cows, but they are not the same chemical. Lactoferrin is more protective of mucosa lining. Apolactoferrin does not have the same iron binding ability. Both have anti-inflammatory, antifungal and antiviral properties.
Jarrow brand has Apolactoferrin which has slightly different mechanism of action than lactoferrin. Both can be derived similarly from cows, but they are not the same chemical. Lactoferrin is more protective of mucosa lining. Apolactoferrin does not have the same iron binding ability. Both have anti-inflammatory, antifungal and antiviral properties.
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