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Bile excretion when having diarrhea?
@orion Thanks. What is strange is that some people who do not know about vitamin A problems do the flushes and get better from their Accutane side effects even if they do not follow a low vit A.
Yes, I agree: the goal is to get the bile out.
@are have you been able to do a flush?
Quote from Gonzalo on December 3, 2020, 1:32 am@orion Thanks. What is strange is that some people who do not know about vitamin A problems do the flushes and get better from their Accutane side effects even if they do not follow a low vit A.
Yes, I agree: the goal is to get the bile out.
@gonzalo I think the number one issue with accutane is glucuronidation, since accutane is not a storage form of vitamin A and is not reversible to a storage form, the body must quickly prioritize its swift removal, and if glucuronidation is impaired, issues will follow. Flushing the liver would beneficial here I think.
@are Well I am no expert, but I suspect any of us that took accutane were already damaged from vitamin A.
From my experience, anecdotal evidence and all the research I have looked through, skin issues(acne, etc...) are related to vitamin A overload, taking accutane is the icing on the cake. Whether you loaded up on VA at birth, genetic excretion factors, high VA diet, etc, before we took accutane something was already wrong.
Being that accutane cannot be stored, and if glucuronidation is impaired, I think a lot of damage to epithelial tissues can occur until high levels of accutane finally gets down to normal excretion levels in the body, like we are all dealing with now. But even now down to normal excretion levels, I would suspect will still have elevated retinoic acid levels from storage. Tested for retinoic acid levels would be a very good thing if we could test it!
I suspect your eyes would improve if you started eating high VA, as you would switch your body to storage mode and retinoic acid levels could fall, but I would never recommend this. Like I have mentioned before, I think time under low VA is the only approach, and look at it year to year. Getting serum VA below 20ug/Dl or close to zero. All foods have VA so I would never worry about deficiency, it is impossible in my mind.
I have just got over 2yrs on low VA and I now seem to be experiencing the real benefits, I see it in my skin health, a real easy marker to follow. So I think I am about half way there, 4yrs under very low VA is the goal now.
@are My staples:
Beef, Chicken, egg white
Rice, potato, breads
Black, Black-eyed, Cannellini beans
High Oleic Safflower (same fat profile as Olive oil, but neutral taste, and lower VA)
Lemonade, maple syrup
Not staples, but eat them:
Onion, garlic, parsnips, celery, peeled apples, strawberry, grapes, pineapple
@are compare them to your olive oil, it should have the similar fat profile, with high amount of mono-unsaturated fat
My per 10ml is :
0.5g Sat
1.0g Poly-Omega6
7.0g Mono
@are I eat potatoes in all forms 🙂 chips, french fries, mashed, baked, fried
@are I recommend following this one: https://www.davidwolfe.com/liver-gallbladder-flush-protocol/
My purges were always yellow-green, and pure liquid, the epsom salt flush is like peeing from your butt 😉 They remained that color with safflower oil which is pretty much colorless.
Also the purges smelled like cooked liver, will never eat liver again in my life, I promise that.
@are @orion I completely agree with: "peeing from your butt". Mine were also yellow.
So I am curious, how is the Accutane still trapped in the body? In the liver?
Regarding meibomian glands, after the first year or two I had extremely dry eyes, I could not read for very long. I did tests and I had disfunction in the glands. I am much better now, like I was before Accutane. I have to go to the doctor to do another test to see if I have reversed the disfunction. But as I feel my eyes are healthy and normal again, I have been postponing it. I can read for hours and hours and no problem, before I had to use drops and blink every second almost.
Quote from Gonzalo on December 3, 2020, 1:15 pmSo I am curious, how is the Accutane still trapped in the body? In the liver?
@gonzalo @are I think for most the accutane should be gone quite quickly, since it cannot be stored it must be excreted. If your glucuronidation was impaired it might take longer. Although I have no idea how fast it is glucuronidated... I don't think it would take months, but who knows. While the high level is circulating lots of damage must be done, especially the sebaceous/meibomian glands, epithelial tissues...
That is great news about your eyes, mine continue to change color back to bright blue, and I hope to continue improving the vision in my left eye, which is weaker than the right.
As well as glucoronidation I think that CYP26 is also required to process Accutane - that’s my understanding. Stephanie Seneff talks about glyphosate affecting the CYP enzymes. I don’t know. I just wonder if non organic food could slow down the breakdown of Accutane. Just an idea. I haven’t looked into it.
Also if excretion is not working properly then the retinoic acid metabolites formed from Accutane & dumped into bile will just recirculate round & round in the enterohepatic circulation. I would think that the whole post ALDH metabolism of vA will need to be working well to get rid of the excess retinoic acid efficiently. I can think of a few places this could go wrong. I would think that Accutane & constipation would be a very bad combination.