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Influence of food on ADH and ALDH activity
I've seen lemon water recommended when trying to cleanse the body.
Although I (purely intuitively) do not believe in the theory of hormesis. I think this is what they want to explain such phenomena as, for example, long-lived alcohol drinkers. I think that when retinol is injected into mice with xerophthalmia caused by oxidized VA metabolites, retinol destroys the ADH cells. Accordingly, mice begin to remove less of these metabolites from the liver and their teratogenic effect on the body decreases. Thus, you can inject retinol and stop the detox, and see temporary improvements. And alcohol, apparently, does something directly with retinol, maybe it dissolves it and removes it in the urine? And the elimination of VA improves, you see more ADH activity, more VA in the tissues and less in the liver. I have nothing to confirm this point of view, this is my intuition.
By the way, perhaps this is why people can react to pork - it can do something (also) with A(L)DH.
As if the main advantage of aspirin was not to slow down detoxification:
https://pubmed.ncbi.nlm.nih.gov/25772736/
"Previous studies have reported that aspirin significantly reduced the first-pass metabolism (FPM) of ethanol in humans thereby increasing adverse effects of alcohol. The underlying causes, however, remain poorly understood. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), principal enzymes responsible for metabolism of ethanol, are complex enzyme families that exhibit functional polymorphisms among ethnic groups and distinct tissue distributions. We investigated the inhibition profiles by aspirin and its major metabolite salicylate of ethanol oxidation by recombinant human ADH1A, ADH1B1, ADH1B2, ADH1B3, ADH1C1, ADH1C2, ADH2, and ADH4, and acetaldehyde oxidation by ALDH1A1 and ALDH2, at pH 7.5 and 0.5 mM NAD(+). Competitive inhibition pattern was found to be a predominant type among the ADHs and ALDHs studied, although noncompetitive and uncompetitive inhibitions were also detected in a few cases. The inhibition constants of salicylate for the ADHs and ALDHs were considerably lower than that of aspirin with the exception of ADH1A that can be ascribed to a substitution of Ala-93 at the bottom of substrate pocket as revealed by molecular docking experiments. Kinetic inhibition equation-based simulations show at higher therapeutic levels of blood plasma salicylate (1.5 mM) that the decrease of activities at 2-10 mM ethanol for ADH1A/ADH2 and ADH1B2/ADH1B3 are predicted to be 75-86% and 31-52%, respectively, and that the activity decline for ALDH1A1 and ALDH2 at 10-50 μM acetaldehyde to be 62-73%. Our findings suggest that salicylate may substantially inhibit hepatic FPM of alcohol at both the ADH and ALDH steps when concurrent intaking aspirin."
Quote from lil chick on August 1, 2021, 3:52 amI've seen lemon water recommended when trying to cleanse the body.
Interestingly, in my country, lemons were discussed as a cure for coronavirus. When this hysteria first started, they cost a lot of money. The grant provided very convincing evidence of the connection between the coronavirus and the toxicity of vitamin A. Maybe this made sense...
I decided to drink lemon juice yesterday. I must say, I really liked it, and I drank quite a lot. And it seems to me that I had eczema yesterday (never before) on the right knee . It's a powerful thing. I think citric acid is the active substance here.
Quote from Даниил on August 5, 2021, 4:51 amI decided to drink lemon juice yesterday. I must say, I really liked it, and I drank quite a lot. And it seems to me that I had eczema yesterday (never before) on the right knee . It's a powerful thing. I think citric acid is the active substance here.
That could be tested by adding baking soda to neutralize the citric acid. From the research, it does seem likely that citric acid is indeed responsible.
If so, there are capsules that ones could take to avoid the acidity on the teeth. Or maybe rinse with baking soda afterwards.
Quote from Даниил on August 1, 2021, 8:22 amAnd alcohol, apparently, does something directly with retinol, maybe it dissolves it and removes it in the urine? And the elimination of VA improves, you see more ADH activity, more VA in the tissues and less in the liver. I have nothing to confirm this point of view, this is my intuition.
This line jumped out at me here. I've never heard anyone suspect that before and what an interesting thought. I have heard people, like Ourania (and myself) say that a little bit of alcohol was a cure for low-grade VA detox symptoms. I've noticed that the urine that is produced is yellower than normal. Perhaps a small amount of alcohol helps push some VA through the kidneys and out.
I would guess there's is a fine line between the "benefit" zone and the "problem" zone here (alcohol as a detox remedy). I've seen many heavier drinkers put on lots of weight, which perhaps tells us that too much VA is being kicked out of the liver and circulating and needing quick storage around the body.
My grandmother (who was naturally low VA and lived a long time) told me if she wanted to loose weight, she only had to quit drinking.
My desire for a small drink each day has not waned, although I've tried and tried to get it out of my lifestyle. I had the "self control" to get rid of the caffeine, which I was physically addicted to. But no such luck with the booze.
Quote from lil chick on August 8, 2021, 10:19 amQuote from Даниил on August 1, 2021, 8:22 amAnd alcohol, apparently, does something directly with retinol, maybe it dissolves it and removes it in the urine? And the elimination of VA improves, you see more ADH activity, more VA in the tissues and less in the liver. I have nothing to confirm this point of view, this is my intuition.
This line jumped out at me here. I've never heard anyone suspect that before and what an interesting thought. I have heard people, like Ourania (and myself) say that a little bit of alcohol was a cure for low-grade VA detox symptoms. I've noticed that the urine that is produced is yellower than normal. Perhaps a small amount of alcohol helps push some VA through the kidneys and out.
I would guess there's is a fine line between the "benefit" zone and the "problem" zone here (alcohol as a detox remedy). I've seen many heavier drinkers put on lots of weight, which perhaps tells us that too much VA is being kicked out of the liver and circulating and needing quick storage around the body.
My grandmother (who was naturally low VA and lived a long time) told me if she wanted to loose weight, she only had to quit drinking.
My desire for a small drink each day has not waned, although I've tried and tried to get it out of my lifestyle. I had the "self control" to get rid of the caffeine, which I was physically addicted to. But no such luck with the booze.
Hi, lil chick 🖐️
https://ggenereux.blog/discussion/topic/alcohol-and-vitamin-a-metabolism/?part=1
In this thread, we discussed a number of mechanisms by which alcohol depletes VA.